REG-3 gamma/REG3G 蛋白, Human (HEK293, Fc)

REG-3 gamma/REG3G protein is a bactericidal C-type lectin that specifically targets Gram-positive bacteria by binding to the peptidoglycan surface moiety, mediating bacterial killing. It limits bacterial colonization of intestinal epithelial surfaces and limits microbiota-induced adaptive immune responses. REG-3 gamma/REG3G Protein, Human (HEK293, Fc) is the recombinant human-derived REG-3 gamma/REG3G protein, expressed by HEK293 , with C-hFc labeled tag.

REG-3 gamma/REG3G 蛋白是一种杀菌 C 型凝集素，通过与肽聚糖表面暴露的碳水化合物部分结合，专门针对革兰氏阳性菌发挥作用，从而介导细菌杀灭。这种蛋白质限制了肠上皮表面的细菌定植，从而限制了微生物群适应性免疫反应的激活。它作为一种激素来响应各种刺激，包括 IL17A 或肠道微生物组等抗炎信号。REG-3 gamma/REG3G 蛋白由不同类型的细胞分泌，激活其受体 EXTL3，从而诱导细胞特异性信号传导途径。在角质形成细胞中，它由 IL17A 诱导，调节皮肤损伤后的角质形成细胞增殖和分化，同时通过抑制 IL6 和 TNF 等炎症细胞因子来抑制皮肤炎症。在肺上皮细胞中，REG-3 gamma/REG3G 蛋白由 IL22 诱导，抑制细胞因子的产生并调节过敏性气道炎症。此外，它是由富含菊粉的饮食和富含格氏乳杆菌的微生物组在小肠中诱导的，有助于改善肠道屏障功能、能量平衡和血糖水平。此外，REG-3 gamma/REG3G 蛋白可调节十二指肠内容物中微生物群的组成。最后，它是由伤害感受器响应内毒素而产生，并通过靶向小胶质细胞中的犬尿氨酸途径来防止内毒素死亡。

Human

HEK293

C-hFc

Q6UW15-1 (E27-D175)

130120  [NCBI]

EETQKELPSPRISCPKGSKAYGSPCYALFLSPKSWMDADLACQKRPSGKLVSVLSGAEGSFVSSLVRSISNSYSYIWIGLHDPTQGSEPDGDGWEWSSTDVMNYFAWEKNPSTILNPGHCGSLSRSTGFLKWKDYNCDAKLPYVCKFKD

Approximately 44-50.0 kDa

Greater than 95% as determined by reducing SDS-PAGE.

溶液

Supplied as a 0.2 μm filtered solution of PBS, pH 7.4 or 20 mM PB, 500 mM NaCl, 10% Glycerol, 0.05% Tween 80, pH 7.5.

<1 EU/μg, determined by LAL method.

Stored at -80°C for 1 year. It is stable at -20°C for 3 months after opening. It is recommended to freeze aliquots at -80°C for extended storage. Avoid repeated freeze-thaw cycles.

Shipping with dry ice.