Resistin 蛋白, Mouse (HEK293, Fc)

Resistin hormone inhibits insulin's efficacy in promoting glucose uptake into adipose cells, potentially linking obesity and diabetes. Structurally, it forms stabilizing disulfide linkages as a homodimer. The interplay between resistin and insulin reveals complex molecular mechanisms in metabolic regulation, providing insights into how resistin may contribute to the pathophysiological connections between obesity and diabetes. Resistin Protein, Mouse (HEK293, Fc) is the recombinant mouse-derived Resistin protein, expressed by HEK293 , with N-hFc labeled tag. The total length of Resistin Protein, Mouse (HEK293, Fc) is 94 a.a., with molecular weight of ~39 kDa.

抵抗素是一种有影响力的激素，它似乎在抑制胰岛素促进脂肪细胞摄取葡萄糖的功效方面发挥着关键作用，从而在肥胖和糖尿病之间建立了潜在的关联。在结构上，它采用同二聚体形式，其特征是稳定的二硫键。抵抗素和胰岛素之间复杂的相互作用强调了代谢调节中涉及的复杂分子机制，为抵抗素的作用如何促进肥胖和糖尿病发展之间的病理生理联系提供了宝贵的见解。

Measured in a cell proliferation assay using PC-3 cells. The ED₅₀ for this effect is 32.38 ng/mL, corresponding to a specific activity is 3.09×10^4 units/mg.

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  Measured in a cell proliferation assay using PC-3 cells. The ED₅₀ for this effect is 32.38 ng/mL, corresponding to a specific activity is 3.09×10⁴ units/mg.

Mouse

HEK293

N-hFc

Q99P87 (S21-S114)

57264  [NCBI]

SSMPLCPIDEAIDKKIKQDFNSLFPNAIKNIGLNCWTVSSRGKLASCPEGTAVLSCSCGSACGSWDIREEKVCHCQCARIDWTAARCCKLQVAS

Approximately 39 kDa

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  Greater than 90% as determined by reducing SDS-PAGE.

无菌粉末.

Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4.

<1 EU/μg, determined by LAL method.

It is not recommended to reconstitute to a concentration less than 100 μg/mL in ddH₂O. For long term storage it is recommended to add a carrier protein (0.1% BSA, 5% HSA, 10% FBS or 5% Trehalose).

Stored at -20°C for 2 years. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.

Room temperature in continental US; may vary elsewhere.