RIOK2 蛋白, Human (Sf9, His, GST)

RIOK2 is an important serine/threonine protein kinase that is critical in the final cytoplasmic maturation phase of the 40S ribosomal subunit. It promotes the export of 40S preribosomal particles from the nucleus to the cytoplasm, which is essential for ribosome biogenesis. RIOK2 Protein, Human (Sf9, His, GST) is the recombinant human-derived RIOK2 protein, expressed by Sf9 insect cells , with N-8*His, N-GST labeled tag. The total length of RIOK2 Protein, Human (Sf9, His, GST) is 551 a.a., .

RIOK2 是一种丝氨酸/苏氨酸蛋白激酶，在 40S 核糖体亚基细胞质成熟的最后阶段发挥着关键作用。它的参与延伸到前 40S 核糖体颗粒从细胞核到细胞质的输出，这是核糖体生物合成中的关键步骤。RIOK2 的激酶活性对于协调 NOB1、PNO1 和 LTV1 从晚期前 40S 亚基的释放以及促进 18S-E 前 rRNA 加工成成熟 18S rRNA 至关重要。除了在核糖体成熟中的作用之外，RIOK2 在细胞周期中还具有调节功能，特别是影响有丝分裂过程中中期-后期转变的时间。这种调节作用可能是通过磷酸化调节的，也可能是通过 PLK1 调节的，这凸显了 RIOK2 对细胞过程的多方面贡献。

Human

Sf9 insect cells

N-8*His;N-GST

Q9BVS4 (G2-E552)

55781

GKVNVAKLRYMSRDDFRVLTAVEMGMKNHEIVPGSLIASIASLKHGGCNKVLRELVKHKLIAWERTKTVQGYRLTNAGYDYLALKTLSSRQVVESVGNQMGVGKESDIYIVANEEGQQFALKLHRLGRTSFRNLKNKRDYHKHRHNVSWLYLSRLSAMKEFAYMKALYERKFPVPKPIDYNRHAVVMELINGYPLCQIHHVEDPASVYDEAMELIVKLANHGLIHGDFNEFNLILDESDHITMIDFPQMVSTSHPNAEWYFDRDVKCIKDFFMKRFSYESELFPTFKDIRREDTLDVEVSASGYTKEMQADDELLHPLGPDDKNIETKEGSEFSFSDGEVAEKAEVYGSENESERNCLEESEGCYCRSSGDPEQIKEDSLSEESADARSFEMTEFNQALEEIKGQVVENNSVTEFSEEKNRTENYNRQDGQRVQGGVPAGSDEYEDECPHLIALSSLNREFRPFRDEENVGAMNQYRTRTLSITSSGSAVSCSTIPPELVKQKVKRQLTKQQKSAVRRRLQKGEANIFTKQRRENMQNIKSSLEAASFWGE

Approximately 90.8 KDa

Greater than 90% as determined by reducing SDS-PAGE.

溶液.

Supplied as a 0.22 μm filtered solution of 50mM HEPES (pH 7.5), 200mM NaCl, 10% glycerol, 5mM DTT, 0.1M Trehalose.

<1 EU/μg, determined by LAL method.

Please use rapid thawing with running water to thaw the protein.

Stored at -80°C for 1 year. It is stable at -20°C for 3 months after opening. It is recommended to freeze aliquots at -80°C for extended storage. Avoid repeated freeze-thaw cycles.

Shipping with dry ice.