RNF114 蛋白, Human (GST)

The RNF114 protein is an E3 ubiquitin protein ligase that critically regulates a variety of cellular processes by ubiquitinating various substrates. RNF114 is involved in cell cycle progression, apoptosis, osteoclastogenesis and immunity, serving as a negative regulator of NF-kappa-B-dependent transcription, affecting immune responses by ubiquitinating TNFAIP3 and potentially TRAF6. RNF114 Protein, Human (GST) is the recombinant human-derived RNF114 protein, expressed by E. coli , with N-GST labeled tag. The total length of RNF114 Protein, Human (GST) is 227 a.a., .

RNF114 蛋白作为 E3 泛素蛋白连接酶，通过促进各种底物的泛素化，在协调多种细胞过程中发挥着关键作用。它具有广泛的影响，参与基本生物过程的调节，包括细胞周期进程、细胞凋亡、破骨细胞生成以及先天性和适应性免疫。RNF114 通过促进 NF-kappa-B 抑制剂 TNFAIP3 和潜在的 TRAF6 的泛素化和稳定，充当 NF-kappa-B 依赖性转录的负调节因子，从而影响免疫反应。此外，它还充当 T 细胞激活的负调节因子，并通过靶向 MAVS 成分进行蛋白酶体降解来阻碍细胞 dsRNA 反应和干扰素产生。通过泛素化 CDK 抑制剂（例如 CDKN1A、CDKN1B 和 CDKN1C），RNF114 刺激 G1-to-S 相变，抑制细胞衰老并可能促进精子发生。这种多方面的活动强调了 RNF114 在控制关键细胞途径和过程中的重要性。

Human

E. coli

N-GST

Q9Y508 (A2-Q228)

55905

Greater than 90% as determined by reducing SDS-PAGE.

<1 EU/μg, determined by LAL method.