ROR1 蛋白, Rat (HEK293, His)

ROR1 Protein, a crucial member of the Tyr protein kinase family within the protein kinase superfamily, plays a key role in cellular signaling and regulation as a tyrosine kinase. Its classification emphasizes its significance in phosphorylation events, sharing conserved features with related kinases. Studying ROR1 contributes to understanding its unique enzymatic functions and potential therapeutic applications. Further exploration promises insights into its broader impact on cellular signaling pathways and contributions to normal physiology and pathological conditions. ROR1 Protein, Rat (HEK293, His) is the recombinant rat-derived ROR1 protein, expressed by HEK293, with C-10*His labeled tag. The total length of ROR1 Protein, Rat (HEK293, His) is 374 a.a., with molecular weight of 60-75 kDa.

ROR1 蛋白是蛋白激酶超家族的关键成员，特别属于 ROR 亚家族中的 Tyr 蛋白激酶家族。它的分类强调了它作为酪氨酸激酶的关键作用，表明它参与细胞信号传导和调节。作为蛋白激酶超家族的一部分，ROR1 可能与相关激酶具有保守的结构和功能特征，强调了其在磷酸化事件中的重要性。Tyr 蛋白激酶家族的命名进一步强调了其在酪氨酸激酶中的特定作用，提供了对其独特酶功能的深入了解。ROR1 的研究有助于我们了解其在与酪氨酸磷酸化相关的细胞过程中的作用，呈现出在治疗干预中的潜在应用，并更深入地理解其对细胞信号传导途径的更广泛影响。对 ROR1 作用的进一步探索有望增强我们对其对正常生理和病理状况的贡献的了解。

Measured by its binding ability in a functional ROR1. Immobilized ROR1 at 2 μg/ml can bind Anti-ROR1 antibody, the ED₅₀ of Rat ROR1 protein is 0.168 μg/mL, corresponding to a specific activity is 5.95×10³ units/mg.

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  Measured by its binding ability in a functional ROR1. Immobilized ROR1 at 2 μg/ml can bind Anti-ROR1 antibody, the ED₅₀ of Rat ROR1 protein is 0.168 μg/mL, corresponding to a specific activity is 5.95×103 units/mg.

Rat

HEK293

C-10*His

D3ZZ97/EDL97819.1 (Q30-E403)

362550  [NCBI]

QETELSVSAELVPTSSWNTSSEIDKDSYLTLDEPMNNITTSLGQTAELHCKVSGNPPPNIRWFKNDAPVVQEPRRISFRATNYGSRLRIRNLDTTDTGYFQCVATSGKKVVSTTGVLFVKFGPPPTASPGSSDEYEEDGFCQPYRGIACARFIGNRTVYMESLHMQGEIENQITAAFTMIGTSSHLSDKCSQFAIPSLCHYAFPYCDETSSVPKPRDLCRDECEVLENVLCHTEYIFARSNPMILMRLKLPNCEDLPQPESPEAANCIRIGIPMADPINKNHKCYNSTGVDYRGTVSVTKSGRQCQPWNSQYPHTHSFTALRFPELNGGHSYCRNPGNQKEAPWCFTLDENFKSDLCDIPACDSKDSKEKNKME

60-75 kDa

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  Greater than 95% as determined by reducing SDS-PAGE.

无菌粉末.

Lyophilized from a 0.22 μm filtered solution of PBS, pH 7.4.

<1 EU/μg, determined by LAL method.

It is not recommended to reconstitute to a concentration less than 100 μg/mL in ddH₂O. For long term storage it is recommended to add a carrier protein (0.1% BSA, 5% HSA, 10% FBS or 5% Trehalose).

Stored at -20°C for 2 years. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.

Room temperature in continental US; may vary elsewhere.