ROR2 蛋白, Human (Biotinylated, HEK293, His-Avi)

The ROR2 protein is a tyrosine protein kinase receptor that plays a critical role in early chondrocyte formation and is essential for cartilage and growth plate development. Phosphorylated YWHAB induces osteogenesis and bone formation. ROR2 Protein, Human (Biotinylated, HEK293, His-Avi) is the recombinant human-derived ROR2 protein, expressed by HEK293 , with C-Avi, C-His labeled tag. The total length of ROR2 Protein, Human (Biotinylated, HEK293, His-Avi) is 370 a.a., with molecular weight of 54-65 kDa.

ROR2 蛋白是一种酪氨酸蛋白激酶受体，在软骨细胞形成的早期阶段发挥着关键作用，被认为对于软骨和生长板的发育至关重要。其YWHAB磷酸化不仅能诱导成骨，还能促进骨形成。尽管在体外表现出最小的酪氨酸激酶活性，ROR2 的复杂作用还延伸到潜在地充当 Wnt 配体 WNT5A 的受体。这种相互作用可能会导致抑制 WNT3A 介导的信号传导的有趣结果。ROR2 的多方面功能凸显了其在协调软骨形成、成骨和 Wnt 信号通路复杂调节等复杂过程中的重要性。

Immobilized Anti-ROR2 Antibody, hFc Tag at 1 μg/mL (100 μl/well) on the plate. Dose response curve for Biotinylated Human ROR2, hFc Tag with the EC₅₀ of ≤10 ng/mL determined by ELISA.

Human

HEK293

C-Avi;C-His

A1L4F5 (V34-G403)

4920

54-65 kDa

Greater than 95% as determined by Tris-Bis PAGE.

无菌粉末

Lyophilized from a 0.22 μm filtered solution of PBS, pH 7.4. Normally 5% trehalose is added as protectant before lyophilization.

<1 EU/μg, determined by LAL method.

It is not recommended to reconstitute to a concentration less than 100 μg/mL in ddH₂O.

Stored at -20°C for 2 years. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.

Room temperature in continental US; may vary elsewhere.