S100A1 蛋白, Human (HEK293, hFc)

The S100A1 gene encodes a protein that regulates cellular processes, with potential roles in Ca2+ release, microtubule assembly, and protein phosphorylation. Decreased expression is linked to cardiomyopathies, highlighting its importance in heart-related conditions. It is abundantly expressed in the heart, salivary gland, and other tissues. S100A1 Protein, Human (HEK293, hFc) is the recombinant human-derived S100A1 protein, expressed by HEK293 , with N-hFc labeled tag. The total length of S100A1 Protein, Human (HEK293, hFc) is 93 a.a., with molecular weight of ~40 kDa.

S100A1 基因编码属于 S100 家族的蛋白质，其特征在于 2 个 EF 手钙结合基序。S100蛋白分布在各种细胞的细胞质和/或细胞核中，在细胞周期进程和分化等细胞过程的调节中发挥作用。该蛋白至少有 13 个成员位于染色体 1q21 上的簇中，可能参与刺激 Ca2+ 诱导的 Ca2+ 释放、抑制微管组装和阻碍蛋白激酶 C 介导的磷酸化。值得注意的是，S100A1 表达减少与心肌病有关，这强调了其在心脏相关疾病中的潜在意义。该基因表现出偏向表达，尤其在心脏、唾液腺和选择的其他组织中丰富。

Measured by its binding ability in a functional ELISA. When Recombinant Human S100A1 is immobilize at 1 μg/mL, 100 μL/well, it binds recombinant human HSP70/HSPA1A with the ED₅₀ value of 2.259 μg/mL.

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  Measured by its binding ability in a functional ELISA. When Recombinant Human S100A1 is immobilize at 1 μg/mL, 100 μL/well, it binds recombinant human HSP70/HSPA1A with the ED₅₀ value of 2.259 μg/mL.

Human

HEK293

N-hFc

NP_006262.1 (G2-S94)

6271  [NCBI]

GSELETAMETLINVFHAHSGKEGDKYKLSKKELKELLQTELSGFLDAQKDVDAVDKVMKELDENGDGEVDFQEYVVLVAALTVACNNFFWENS

Approximately 40 kDa

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  Greater than 95% as determined by reducing SDS-PAGE.

无菌粉末.

Lyophilized from a 0.2 μm filtered solution of 50 mM Tris, 10 mM NaCl, pH 7.5.

<1 EU/μg, determined by LAL method.

It is not recommended to reconstitute to a concentration less than 100 μg/mL in ddH₂O. For long term storage it is recommended to add a carrier protein (0.1% BSA, 5% HSA, 10% FBS or 5% Trehalose).

Stored at -20°C for 2 years. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.

Room temperature in continental US; may vary elsewhere.