Semaphorin-6A/SEMA6A 蛋白, Human (HEK293, His)

Semaphorin-6A (SEMA6A) is the cell surface receptor for PLXNA2 and plays a key role in intercellular signaling. Its importance extends to the coordination of normal granule cell migration within the developing cerebellum and the promotion of actin cytoskeletal reorganization, which is critical for axonal guidance in the developing central nervous system. Semaphorin-6A/SEMA6A Protein, Human (HEK293, His) is the recombinant human-derived Semaphorin-6A/SEMA6A protein, expressed by HEK293 , with C-His labeled tag.

Semaphorin-6A (SEMA6A) 是 PLXNA2 的细胞表面受体，在细胞间信号传导中至关重要，并在各种发育过程中发挥重要作用。它对于发育中小脑中的正常颗粒细胞迁移至关重要，并通过促进肌动蛋白细胞骨架重组在中枢神经系统内的轴突引导中发挥关键作用。作为排斥性轴突引导信号，SEMA6A 对迁移的颗粒神经元表现出排斥作用。此外，它可能有助于将交感神经轴突引导至交感神经链并调节交感神经靶标神经支配的时间顺序。在微生物感染的情况下，SEMA6A 充当血管内皮中 P. sordellii 毒素 TcsL 的受体。因此，这种多面蛋白质在发育过程中和应对微生物挑战时协调细胞运动和轴突引导方面发挥着关键作用。

Human

HEK293

C-His

Q9H2E6-1 (G19-T649)

57556  [NCBI]

GFPEDSEPISISHGNYTKQYPVFVGHKPGRNTTQRHRLDIQMIMIMNGTLYIAARDHIYTVDIDTSHTEEIYCSKKLTWKSRQADVDTCRMKGKHKDECHNFIKVLLKKNDDALFVCGTNAFNPSCRNYKMDTLEPFGDEFSGMARCPYDAKHANVALFADGKLYSATVTDFLAIDAVIYRSLGESPTLRTVKHDSKWLKEPYFVQAVDYGDYIYFFFREIAVEYNTMGKVVFPRVAQVCKNDMGGSQRVLEKQWTSFLKARLNCSVPGDSHFYFNILQAVTDVIRINGRDVVLATFSTPYNSIPGSAVCAYDMLDIASVFTGRFKEQKSPDSTWTPVPDERVPKPRPGCCAGSSSLERYATSNEFPDDTLNFIKTHPLMDEAVPSIFNRPWFLRTMVRYRLTKIAVDTAAGPYQNHTVVFLGSEKGIILKFLARIGNSGFLNDSLFLEEMSVYNSEKCSYDGVEDKRIMGMQLDRASSSLYVAFSTCVIKVPLGRCERHGKCKKTCIASRDPYCGWIKEGGACSHLSPNSRLTFEQDIERGNTDGLGDCHNSFVALNGHSSSLLPSTTTSDSTAQEGYESRGGMLDWKHLLDSPDSTDPLGAVSSHNHQDKKGVIRESYLKGHDQLVPVT

Approximately 85-110 kDa

Greater than 95% as determined by reducing SDS-PAGE

<1 EU/μg, determined by LAL method.