Serpin A6 蛋白, Mouse (HEK293, His)

Serpin A6 Protein serves as the primary transport protein for glucocorticoids and progestins in the blood of nearly all vertebrate species. Serpin A6 Protein, Mouse (HEK293, His) is the recombinant mouse-derived Serpin A6 protein, expressed by HEK293 , with C-His labeled tag. The total length of Serpin A6 Protein, Mouse (HEK293, His) is 375 a.a., with molecular weight of 50-60 kDa.

丝氨酸蛋白酶抑制剂 A6，也称为皮质类固醇结合球蛋白 (CBG)，是一种糖蛋白，可作为血液中皮质类固醇（包括皮质醇）的载体。CBG 在调节皮质类固醇的水平和可用性方面发挥着至关重要的作用，这对于各种生理过程很重要，包括应激反应、免疫功能和新陈代谢。它以高亲和力与皮质醇结合，影响其在体内的分布和活性。SERPINA6 基因的突变或改变会影响 CBG 功能和皮质类固醇稳态。

Measured by its binding ability in a functional ELISA. When Cortisol-BSA Conjugate is immobilized at 5 μg/mL, 100 μL/well can bind Recombinant Human Serpin A6. The ED₅₀ for this effect is 5.447 μg/mL.

• 
  Measured by its binding ability in a functional ELISA. When Cortisol-BSA Conjugate is immobilized at 5 μg/mL, 100 μL/well can bind Recombinant Human Serpin A6 . The ED₅₀ for this effect is 5.447 μg/mL.

Mouse

HEK293

C-His

Q06770 (V23-A397)

12401  [NCBI]

VTDEDSSSHRDLAPTNVDFAFNLYKRLVALNSDKNTLISPVSISMALAMLSLSTRGSTQYLENLGFNMSKMSEAEIHQGFQYLNSLLQQSDTGLEMNMGNVMFLLQNLKLKDSFLADTKHYYESEALTIPSKDWTKAGEQINNHVKNKTQGKIEHVVSDLDSSATLILINYIFLKGIWKLPFSPENTREEDFYVNETSTVKVPMMVQSGNISYFRDSAIPCQMVQMNYVGNGTTFIILPDQGQMDTVVAALNRDTIDRWGKLMIPRQMNLYIPKFSMSDTYDLQDVLADVGIKDLFTNQSDFADTTKDTPLTLTVLHKAMLQLDEGNVLPAATNGPPVHLPSESFTLKYNRPFIFLAFDKYTWSSLMMSQVMNPA

Approximately 50-80 kDa due to the glycosylation

• 
  Greater than 95% as determined by reducing SDS-PAGE.

无菌粉末

Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4.

<1 EU/μg, determined by LAL method.

It is not recommended to reconstitute to a concentration less than 100 μg/mL in ddH₂O. For long term storage it is recommended to add a carrier protein (0.1% BSA, 5% HSA, 10% FBS or 5% Trehalose).

Stored at -20°C for 2 years. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.

Room temperature in continental US; may vary elsewhere.