Sialidase-1 蛋白, Human (HEK293, His)

The Sialidase-1 protein plays a crucial role in cellular processes by catalyzing the removal of the sialic acid (N-acetylneuraminic acid) moiety from glycoproteins and glycolipids. Its enzymatic activity is strictly dependent on its presence in multienzyme complexes, emphasizing the cooperative nature of its function. Sialidase-1 Protein, Human (HEK293, His) is the recombinant human-derived Sialidase-1 protein, expressed by HEK293 , with C-6*His labeled tag. The total length of Sialidase-1 Protein, Human (HEK293, His) is 368 a.a., with molecular weight of 39-50 kDa.

Sialidase-1 蛋白是一种催化从糖蛋白和糖脂中去除唾液酸（N-乙酰神经氨酸）部分的酶。其活性严格取决于其在多酶复合物中的存在。Sialidase-1 表现出优先裂解 α 2-3 和 α 2-6 唾液酸键，表明其对特定类型的唾液酸修饰具有特异性。通过去除唾液酸残基，Sialidase-1 在调节糖复合物的结构和功能、影响细胞相互作用、免疫识别和各种信号传导途径方面发挥着至关重要的作用。该酶对特定唾液酸连接的偏好表明它参与调节受唾液酸修饰影响的不同生物过程。参考资料：所提供的信息基于截至 2022 年 1 月的一般知识，未引用具体参考资料。

The enzyme activity of this recombinant protein is testing in progress, we cannot offer a guarantee yet.

Human

HEK293

C-6*His

Q99519 (E48-L415)

4758  [NCBI]

ENDFGLVQPLVTMEQLLWVSGRQIGSVDTFRIPLITATPRGTLLAFAEARKMSSSDEGAKFIALRRSMDQGSTWSPTAFIVNDGDVPDGLNLGAVVSDVETGVVFLFYSLCAHKAGCQVASTMLVWSKDDGVSWSTPRNLSLDIGTEVFAPGPGSGIQKQREPRKGRLIVCGHGTLERDGVFCLLSDDHGASWRYGSGVSGIPYGQPKQENDFNPDECQPYELPDGSVVINARNQNNYHCHCRIVLRSYDACDTLRPRDVTFDPELVDPVVAAGAVVTSSGIVFFSNPAHPEFRVNLTLRWSFSNGTSWRKETVQLWPGPSGYSSLATLEGSMDGEEQAPQLYVLYEKGRNHYTESISVAKISVYGTL

39-50 kDa

Greater than 95% as determined by reducing SDS-PAGE.

溶液.

Supplied as a 0.2 μm filtered solution of 20 mM PB, 150 mM NaCl, 10% Glycerol, pH 7.4.

<1 EU/μg, determined by LAL method.

Stored at -80°C for 1 year. It is stable at -20°C for 3 months after opening. It is recommended to freeze aliquots at -80°C for extended storage. Avoid repeated freeze-thaw cycles.

Shipping with dry ice.