SLAMF2/CD48 蛋白, Human (HEK293, hFc)

SLAMF2/CD48 protein is a GPI-anchored glycoprotein that regulates immune cell function by interacting with CD2 and CD244. SLAMF2/CD48 Protein, Human (HEK293, hFc) is the recombinant human-derived SLAMF2/CD48 protein, expressed by HEK293 , with C-hFc labeled tag. The total length of SLAMF2/CD48 Protein, Human (HEK293, hFc) is 194 a.a., with molecular weight of ~66 kDa.

SLAMF2/CD48 蛋白是一种糖基磷脂酰肌醇 (GPI) 锚定的细胞表面糖蛋白，通过其 N 端免疫球蛋白结构域与细胞表面受体（如 2B4/CD244 或 CD2）相互作用，在免疫细胞调节和激活中发挥关键作用。在T细胞信号转导中，SLAMF2与CD2结合，促进Src家族蛋白激酶LCK和LAT有效招募至TCR/CD3复合物，从而促进LCK磷酸化和随后的激活。此外，SLAMF2 诱导 CD244 的细胞质免疫受体酪氨酸开关基序 (ITSM) 磷酸化，启动一系列信号传导事件，最终形成免疫突触，并通过 T 淋巴细胞和颗粒酶直接释放含有穿孔素和颗粒酶的溶细胞颗粒。NK 细胞。值得注意的是，SLAMF2 直接与 CD2、CD244 和 LCK 相互作用，突显其在免疫细胞功能和信号通路中的复杂参与。

Measured by its binding ability in a functional ELISA. Immobilized CD48 at 2 μg/mL can bind Anti-CD48 rabbit monoclonal antibody, the EC₅₀ of human CD48 protein is 0.7847-1.107 ng/mL.

Human

HEK293

C-hFc

P09326 (Q27-S220)

962  [NCBI]

QGHLVHMTVVSGSNVTLNISESLPENYKQLTWFYTFDQKIVEWDSRKSKYFESKFKGRVRLDPQSGALYISKVQKEDNSTYIMRVLKKTGNEQEWKIKLQVLDPVPKPVIKIEKIEDMDDNCYLKLSCVIPGESVNYTWYGDKRPFPKELQNSVLETTLMPHNYSRCYTCQVSNSVSSKNGTVCLSPPCTLARS

Approximately 66 kDa

• 
  Greater than 92% as determined by reducing SDS-PAGE.

无菌粉末.

Lyophilized from a 0.2 μm solution of PBS, 6% Trehalose, pH 7.4.

<1 EU/μg, determined by LAL method.

It is not recommended to reconstitute to a concentration less than 100 μg/mL in ddH₂O.

Stored at -20°C for 2 years. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.

Room temperature in continental US;may vary elsewhere.