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  3. SLC17A3 蛋白, Human (Sf9, His, MBP, FLAG)

SLC17A3 蛋白, Human (Sf9, His, MBP, FLAG)

目录号: HY-P702027
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SLC17A3 是一种电压驱动的有机阴离子转运蛋白,在肾近曲小管中发挥着关键作用。它积极促进尿酸盐分泌,对于消除嘌呤代谢的终产物至关重要。SLC17A3 蛋白, Human (Sf9, His, MBP, FLAG) 是重组的 SLC17A3 蛋白,由 Sf9 insect cells 表达,带有 N-MBP, C-Flag, N-8*His 标签。SLC17A3 蛋白, Human (Sf9, His, MBP, FLAG) 全长 419 个氨基酸。

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描述

SLC17A3 is a voltage-driven organic anion transporter that plays a critical role in the renal proximal tubule. It actively promotes urate secretion and is essential for the elimination of the end products of purine metabolism. SLC17A3 Protein, Human (Sf9, His, MBP, FLAG) is the recombinant human-derived SLC17A3 protein, expressed by Sf9 insect cells , with N-MBP, C-Flag, N-8*His labeled tag. The total length of SLC17A3 Protein, Human (Sf9, His, MBP, FLAG) is 419 a.a., .

研究背景

SLC17A3 作为电压驱动的多特异性有机阴离子转运蛋白发挥着关键作用,主要位于肾近曲小管的顶端表面。值得注意的是,它积极促进尿酸盐从细胞分泌到肾小管腔,在消除尿酸盐(嘌呤代谢的最终产物)方面发挥着至关重要的作用。除了参与尿酸盐处理之外,SLC17A3 还可能对多种化合物的代谢和分泌产生影响,包括硫酸雌酮、雌二醇-17-β-葡萄糖醛酸、赭曲霉毒素 A 和某些药物(如布美他尼)。SLC17A3 的多方面转运功能强调了其在肾脏生理学中的重要性,特别是在尿酸盐消除和多种有机阴离子处理的复杂过程中。

种属

Human

表达系统

Sf9 insect cells

标签

N-MBP;C-Flag;N-8*His

蛋白编号

O00476 (A2-L420)

基因 ID

10786

蛋白结构
N-term
8*His-MBP
SLC17A3 (A2-L420)
Accession # O00476
Flag
C-term
同用名
SLC17A3; Sodium-dependent phosphate transport protein 4; Na(+)/PI cotransporter 4; Sodium/phosphate cotransporter 4; Solute carrier family 17 member 3
纯度

Greater than 90% as determined by reducing SDS-PAGE.

内毒素含量

<1 EU/μg, determined by LAL method.

文件资料

SLC17A3 Protein, Human (Sf9, His, MBP, FLAG) 相关分类

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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The reconstitution calculator equation

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration
= ÷

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2

The specific activity calculator equation

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)
Unit/mg = 106 ÷ ng/mL

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SLC17A3 Protein, Human (Sf9, His, MBP, FLAG)
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HY-P702027
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