SMPD2 蛋白, Human (Cell-Free, His)

In vitro experiments have demonstrated that the sphingomyelin phosphodiesterase 2 (SMPD2) protein plays a key role in catalyzing the hydrolysis of sphingomyelin, leading to the formation of ceramide and phosphocholine. Furthermore, SMPD2 exhibits its enzymatic activity by hydrolyzing 1-O-alkyl-2-lyso-sn-glycero-3-phosphocholine (hemolytic platelet-activating factor) in vivo. SMPD2 Protein, Human (Cell-Free, His) is the recombinant human-derived SMPD2 protein, expressed by E. coli Cell-free , with N-10*His labeled tag. The total length of SMPD2 Protein, Human (Cell-Free, His) is 423 a.a., with molecular weight of 49.1 kDa.

鞘磷脂磷酸二酯酶 2 (SMPD2) 是一种催化鞘磷脂水解、将其裂解为神经酰胺和磷酸胆碱的酶。这种酶活性对于鞘脂代谢和细胞信号传导的调节至关重要。SMPD2 还参与体内 1-O-烷基-2-lyso-sn-glycero-3-磷酸胆碱（特别是溶血血小板激活因子）的水解。此外，SMPD2 作用于 1-酰基-2-lyso-sn-glycero-3-磷酸胆碱 (lyso-PC) 和鞘氨醇磷酸胆碱。SMPD2 的多种底物特异性突出了其在调节生物活性脂质分子（包括神经酰胺和溶血磷脂）水平中的作用，这些分子参与各种细胞过程，包括细胞增殖、凋亡和炎症。了解 SMPD2 的功能有助于深入了解脂质代谢的复杂调节及其对细胞稳态的影响。

Human

E. coli Cell-free

N-10*His

O60906 (M1-Q423)

6610

MKPNFSLRLRIFNLNCWGIPYLSKHRADRMRRLGDFLNQESFDLALLEEVWSEQDFQYLRQKLSPTYPAAHHFRSGIIGSGLCVFSKHPIQELTQHIYTLNGYPYMIHHGDWFSGKAVGLLVLHLSGMVLNAYVTHLHAEYNRQKDIYLAHRVAQAWELAQFIHHTSKKADVVLLCGDLNMHPEDLGCCLLKEWTGLHDAYLETRDFKGSEEGNTMVPKNCYVSQQELKPFPFGVRIDYVLYKAVSGFYISCKSFETTTGFDPHRGTPLSDHEALMATLFVRHSPPQQNPSSTHGPAERSPLMCVLKEAWTELGLGMAQARWWATFASYVIGLGLLLLALLCVLAAGGGAGEAAILLWTPSVGLVLWAGAFYLFHVQEVNGLYRAQAELQHVLGRAREAQDLGPEPQPALLLGQQEGDRTKEQ

49.1 kDa

Greater than 90% as determined by reducing SDS-PAGE.

<1 EU/μg, determined by LAL method.