Sox2 蛋白, Human

Sox2 protein is a key transcription factor that forms a trimeric complex with OCT4 and controls the expression of genes critical for embryonic development (YES1, FGF4, UTF1, ZFP206). It binds the NANOG enhancer and is critical for early embryogenesis and stem cell pluripotency. Sox2 Protein, Human is the recombinant human-derived Sox2 protein, expressed by E. coli , with tag free. The total length of Sox2 Protein, Human is 84 a.a., .

Sox2 是一种关键转录因子，与 DNA 上的 OCT4 形成三聚体复合物，控制胚胎发育中至关重要的基因的表达，例如 YES1、FGF4、UTF1 和 ZFP206。它与 NANOG 的近端增强子区域结合，在早期胚胎发生和维持胚胎干细胞多能性中发挥关键作用。作为 SRRT 的下游靶标，Sox2 有助于促进神经干细胞自我更新，同时通过对抗原神经蛋白来防止神经细胞分化。此外，它可能充当神经元发育的开关。Sox2 参与各种相互作用，包括与 ZSCAN10、SOX3、FGFR1、GLIS1、POU5F1、DDX56、L3MBTL3、DCAF5、RCOR1/CoREST、PHF20L1 和 TRIM26 的相互作用，强调其动态调控网络。这些相互作用凸显了它参与关键的细胞过程，包括泛素化、降解保护和通过特定连接酶防止泛素化。

Human

E. coli

Tag Free

P48431 (R40-D123)

6657

Approximately 10.4 KDa

Greater than 90% as determined by reducing SDS-PAGE.

溶液.

Supplied as a 0.22 μm filtered solution of 50 mM Tris, pH7.5, 150 mM NaCl, 5% glycerol.

<1 EU/μg, determined by LAL method.

Please use rapid thawing with running water to thaw the protein.

Stored at -80°C for 1 year. It is stable at -20°C for 3 months after opening. It is recommended to freeze aliquots at -80°C for extended storage. Avoid repeated freeze-thaw cycles.

Shipping with dry ice.