SP-D 蛋白, Human (HEK293, His)

The SP-D protein plays a critical role in the lung's defense mechanisms against inhaled microorganisms, organic antigens, and toxins. This multifunctional protein interacts with a variety of compounds, including bacterial lipopolysaccharides, oligosaccharides, and fatty acids, to modulate leukocyte activity in immune responses. SP-D Protein, Human (HEK293, His) is the recombinant human-derived SP-D protein, expressed by HEK293 , with C-6*His labeled tag. The total length of SP-D Protein, Human (HEK293, His) is 355 a.a., with molecular weight of ~45.0 kDa.

SP-D 蛋白在增强肺部防御吸入微生物、有机抗原和毒素的防御机制方面发挥着至关重要的作用。它与多种化合物结合，包括细菌脂多糖、寡糖和脂肪酸，从而影响免疫反应中的白细胞活性。此外，SP-D 参与细胞外重组或肺表面活性物质的周转，有助于维持呼吸功能。该蛋白质对麦芽糖残基表现出很强的结合亲和力，并且在较小程度上对其他α-葡萄糖基部分表现出很强的结合亲和力。值得注意的是，SP-D 形成包含四组同源三聚体的寡聚复合物，强调其结构组织促进其多样化功能（参考：未提供）。

Human

HEK293

C-6*His

AAH22318.1 (A21-F375)

6441  [NCBI]

AGMKTYSHRTMPSACTLVMCSSVESGLPGRDGRDGREGPRGEKGDPGLPGAAGQAGMPGQAGPVGPKGDNGSVGEPGPKGDTGPSGPPGPPGVPGPAGREGPLGKQGNIGPQGKPGPKGEAGPKGEVGAPGMQGSAGARGLAGPKGERGVPGERGVPGNTGAAGSAGAMGPQGSPGARGPPGLKGDKGIPGDKGAKGESGLPDVASLRQQVEALQGQVQHLQAAFSQYKKVELFPNGQSVGEKIFKTAGFVKPFTEAQLLCTQAGGQLASPRSAAENAALQQLVVAKNEAAFLSMTDSKTEGKFTYPTGESLVYSNWAPGKPNDDGGSEDCVEIFTNGKWNDRACGEKRLVVCEF

Approximately 45.0 kDa

Greater than 95% as determined by reducing SDS-PAGE.

无菌粉末.

Lyophilized from a 0.2 μm filtered solution of 20 mM PB, 150 mM NaCl, pH 7.2.

<1 EU/μg, determined by LAL method.

It is not recommended to reconstitute to a concentration less than 100 μg/mL in ddH₂O. For long term storage it is recommended to add a carrier protein (0.1% BSA, 5% HSA, 10% FBS or 5% Trehalose).

Stored at -20°C for 2 years. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.

Room temperature in continental US;may vary elsewhere.