STAT6 蛋白, Human (His)

STAT6 is a multifunctional protein that performs dual functions of signal transduction and transcriptional activation. It plays a crucial role in mediating IL4/interleukin-4 and IL3/interleukin-3 induced signaling cascades. STAT6 Protein, Human (His) is the recombinant human-derived STAT6 protein, expressed by E. coli , with C-6*His labeled tag. The total length of STAT6 Protein, Human (His) is 211 a.a..

STAT6（信号转导和转录激活剂6）是一种多功能蛋白，在信号转导和转录激活中发挥双重作用。它特别参与介导白细胞介素 4 (IL-4) 和白细胞介素 3 (IL-3) 触发的信号传导通路。STAT6可以与相关家族成员形成同二聚体或异二聚体，促进其参与各种细胞过程。此外，STAT6 通过其 C 端 LXXLL 基序与核受体共激活剂 NCOA1 相互作用，表明其在调节基因表达方面具有潜在作用。这种相互作用进一步强调了 STAT6 参与转录调控，突出了它在协调细胞通路中的信号事件和转录反应方面的多功能性。

Human

E. coli

C-6*His

P42226 (S627-S837)

6778  [NCBI]

SHYKPEQMGKDGRGYVPATIKMTVERDQPLPTPELQMPTMVPSYDLGMAPDSSMSMQLGPDMVPQVYPPHSHSIPPYQGLSPEESVNVLSAFQEPHLQMPPSLGQMSLPFDQPHPQGLLPCQPQEHAVSSPDPLLCSDVTMVEDSCLSQPVTAFPQGTWIGEDIFPPLLPPTEQDLTKLLLEGQGESGGGSLGAQPLLQPSHYGQSGISMS

Approximately 30.0 kDa

Greater than 90% as determined by reducing SDS-PAGE.

无菌粉末

Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4.

<1 EU/μg, determined by LAL method.

It is not recommended to reconstitute to a concentration less than 100 μg/mL in ddH₂O. For long term storage it is recommended to add a carrier protein (0.1% BSA, 5% HSA, 10% FBS or 5% Trehalose).

Stored at -20°C for 2 years. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.

Room temperature in continental US; may vary elsewhere.