SULT1A3 蛋白, Human (N-His)

SULT1A3 protein, a sulfotransferase utilizing PAPS, catalyzes the sulfate conjugation of phenolic monoamines, including neurotransmitters (dopamine, norepinephrine, serotonin) and drugs. This activity contributes significantly to inactivation and elimination, emphasizing SULT1A3's crucial role in regulating neurotransmitter and drug levels, maintaining homeostasis, and ensuring proper biological system functioning. SULT1A3 Protein, Human (N-His) is the recombinant human-derived SULT1A3, expressed by E. coli , with N-6*His labeled tag. ,

SULT1A3 蛋白是一种利用 3'-磷酸-5'-腺苷基硫酸盐 (PAPS) 作为磺酸盐供体的磺基转移酶，在催化酚类单胺（包括多巴胺、去甲肾上腺素和血清素等神经递质）的硫酸盐结合中发挥着关键作用如酚类和儿茶酚类药物。这种酶活性对这些生物活性分子的失活和消除有显着贡献，凸显了 SULT1A3 在调节神经递质和某些药理学相关化合物的水平和活性方面的关键作用。SULT1A3 的底物特异性强调了其在调节对神经递质和药物的生理反应中的重要性，强调了其在维持生物系统的稳态和正常功能方面的重要性。

Measured by its ability to transfer sulfate from PAPS to 1-Napthol. The specific activity is 855.567 pmol/min/μg that incubate at 37 ºC for 20 minutes.

Human

E. coli

N-6*His

P0DMM9-1 (M1-L295)

445329

MELIQDTSRPPLEYVKGVPLIKYFAEALGPLQSFQARPDDLLINTYPKSGTTWVSQILDMIYQGGDLEKCNRAPIYVRVPFLEVNDPGEPSGLETLKDTPPPRLIKSHLPLALLPQTLLDQKVKVVYVARNPKDVAVSYYHFHRMEKAHPEPGTWDSFLEKFMAGEVSYGSWYQHVQEWWELSRTHPVLYLFYEDMKENPKREIQKILEFVGRSLPEETMDFMVQHTSFKEMKKNPMTNYTTVPQELMDHSISPFMRKGMAGDWKTTFTVAQNERFDADYAEKMAGCSLSFRSEL

Approximately 35 kDa.

• 
  Greater than 95% as determined by reducing SDS-PAGE.

无菌粉末

Lyophilized from a 0.22 μm filtered solution of PBS, pH 7.4, 8% trehalose, 8% mannitol and 0.02% Tween80.

<1 EU/μg, determined by LAL method.

It is not recommended to reconstitute to a concentration less than 100 μg/mL in ddH₂O. For long term storage it is recommended to add a carrier protein (0.1% BSA, 5% HSA, 10% FBS or 5% Trehalose).

Stored at -20°C for 2 years. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.

Room temperature in continental US; may vary elsewhere.