SULT1B1 蛋白, Human (His)

Sulfotransferase 1B1 (SULT1B1) is a sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) as sulfonate donor to catalyze the sulfate conjugation of dopamine, small phenols such as 1-naphthol and p-nitrophenol, thyroid hormones and many xenobiotic compounds.SULT1B1 may play a role in gut microbiota-host metabolic interaction.SULT1B1 Protein, Human (His) is the recombinant human-derived SULT1B1 protein, expressed by E.coli , with N-6*His labeled tag.

磺胺转移酶 1B1 (SULT1B1) 是一种以 3'-磷酸-5'-腺苷酸硫酸酯 (PAPS) 为磺酸盐供体，催化多巴胺、1-萘酚、对硝基酚等小酚类物质与 3,3'-二碘甲状腺原氨酸、三碘甲状腺原氨酸 (T3)、逆三碘甲状腺原氨酸 (rT3) 等甲状腺激素的磺酸盐偶联的磺胺转移酶。
SULT1B1 可能在肠道微生物-宿主代谢相互作用中发挥作用，SULT1B1的产物之一，衍生自肠道细菌产生的膳食酪氨酸衍生代谢物的 4-EPS，可穿过血脑屏障，负调控少突胶质细胞成熟和髓鞘形成，影响与边缘系统相关的大脑不同区域的功能连接^[1][2][3][4]。

Measured by its ability to transfer sulfate from PAPS to 1-Napthol. The specific activity is 37.98 pmol/min/μg that incubate at 37°C for 20 minutes.

Human

E. coli

N-6*His

AAH10895.1 (M1-I296)

27284  [NCBI]

MLSPKDILRKDLKLVHGYPMTCAFASNWEKIEQFHSRPDDIVIATYPKSGTTWVSEIIDMILNDGDIEKCKRGFITEKVPMLEMTLPGLRTSGIEQLEKNPSPRIVKTHLPTDLLPKSFWENNCKMIYLARNAKDVSVSYYHFDLMNNLQPFPGTWEEYLEKFLTGKVAYGSWFTHVKNWWKRKEEHPILFLYYEDMKENPKEEIKKIIRFLEKNLNDEILDRIIHHTSFEVMKDNPLVNYTHLPTTVMDHSKSPFMRKGTAGDWKNYFTVAQNEKFDAIYETEMSKTALQFRTEI

28-35 kDa

Greater than 95% as determined by reducing SDS-PAGE.

溶液.

Supplied as a 0.2 μm filtered solution of 20 mM Tris-HCl, 100 mM NaCl, pH 8.0.

<1 EU/μg, determined by LAL method.

Stored at -80°C for 1 year. It is stable at -20°C for 3 months after opening. It is recommended to freeze aliquots at -80°C for extended storage. Avoid repeated freeze-thaw cycles.

Shipping with dry ice.