TFF2 蛋白, Human (His)

TFF2 Protein, a pivotal regulator in the gastrointestinal tract, inhibits gastrointestinal motility and gastric acid secretion. Its potential role as a structural component in gastric mucus is indicated, suggesting contributions to glycoprotein stabilization through interactions with carbohydrate side chains. This multifunctional role underscores TFF2's importance in preserving the integrity and homeostasis of the gastric environment. TFF2 Protein, Human (His) is the recombinant human-derived TFF2 protein, expressed by E. coli , with N-6*His labeled tag. The total length of TFF2 Protein, Human (His) is 106 a.a., with molecular weight of ~14 kDa.

TFF2蛋白通过抑制胃肠道运动和胃酸分泌在胃肠道中发挥调节作用。有人认为它可能作为胃粘液的结构成分，其中它可能通过与碳水化合物侧链的相互作用有助于稳定粘液凝胶内的糖蛋白。这种多方面的功能使 TFF2 成为维持胃环境完整性和稳态的关键参与者。

Measured by its ability to chemoattract bioassay using human MCF-7 cells. The ED₅₀ for this effect is 20.9 ng/mL, corresponding to a specific activity is 4.7846×10⁴ units/mg.

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  Measured by its ability to chemoattract bioassay using human MCF-7 cells. The ED₅₀ for this effect is 20.9 ng/mL, corresponding to a specific activity is 4.7846×10⁴ units/mg.

Human

E. coli

N-6*His

Q03403 (E24-Y129)

7032  [NCBI]

EKPSPCQCSRLSPHNRTNCGFPGITSDQCFDNGCCFDSSVTGVPWCFHPLPKQESDQCVMEVSDRRNCGYPGISPEECASRKCCFSNFIFEVPWCFFPKSVEDCHY

Approximately 14 kDa

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  Greater than 95% as determined by reducing SDS-PAGE.

无菌粉末.

Lyophilized from a 0.2 μm filtered solution of 50 mM Tris-HCL, 300 mM NaCl, 200 mM arginine, pH 8.0.

<1 EU/μg, determined by LAL method.

It is not recommended to reconstitute to a concentration less than 100 μg/mL in ddH₂O. For long term storage it is recommended to add a carrier protein (0.1% BSA, 5% HSA, 10% FBS or 5% Trehalose).

Stored at -20°C for 2 years. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.

Room temperature in continental US; may vary elsewhere.