1. Gene
  2. TFF2 - trefoil factor 2 Gene

TFF2 - trefoil factor 2 Gene

中文名称:三叶因子 2

种属: Homo sapiens

同用名: SP; SML1

基因 ID: 7032 | 基因类型: protein coding

关于 TFF2

Cytogenetic location: 21q22.3 Genomic coordinates (GRCh38): 21:42,346,357-42,350,994 (from NCBI)

This gene has 3 transcripts (splice variants), 121 orthologues and 2 paralogues. Restricted expression toward stomach (RPKM 2591.2).

功能概要

三叶草家族成员的特征是至少有一份三叶草图案,这是一个包含三个保守二硫化物的 40 氨基酸结构域。它们是在胃肠粘膜中表达的稳定分泌蛋白。它们的功能尚未确定,但它们可以保护粘膜免受损伤、稳定粘液层并影响上皮细胞的愈合。编码的蛋白质抑制胃酸分泌。该基因和其他两个相关的三叶草家族成员基因位于 21 号染色体上的一个簇中。[RefSeq 提供,2008 年 7 月]

Members of the trefoil family are characterized by having at least one copy of the trefoil motif, a 40-amino acid domain that contains three conserved disulfides. They are stable secretory proteins expressed in gastrointestinal mucosa. Their functions are not defined, but they may protect the mucosa from insults, stabilize the mucus layer and affect healing of the epithelium. The encoded protein inhibits gastric acid secretion. This gene and two other related trefoil family member genes are found in a cluster on chromosome 21. [provided by RefSeq, Jul 2008]

TFF2 基因产物(1)

mRNA Protein Name
NM_005423.5 NP_005414.1 trefoil factor 2 precursor
基因本体论
  • 分子功能
分子功能 GO 注释 逻辑证据 参考文献 来源
enables protein binding IPI
IPI: 通过物理相互作用推断
21982860 GOA
EXP:通过实验结果推断 IDA:通过直接分析推断 IPI:通过物理相互作用推断 IMP:通过突变表型推断 IGI:通过遗传相互作用推断 IEP:通过表达模式推断

TFF2 蛋白结构

Trefoil

Trefoil: Trefoil (P-type) domain (30 - 72)

Trefoil

Trefoil: Trefoil (P-type) domain (80 - 121)

  • 0
  • 100
  • 129 a.a.
蛋白主名 其他名称

trefoil factor 2

spasmolysin

重组 TFF2 蛋白

目录号 产品名 蛋白编号 纯度
HY-P71354 TFF2 Protein, Human (HEK293, His) Q03403 (E24-Y129) ≥95%
HY-P71929A TFF2 Protein, Human (His) Q03403 (E24-Y129) ≥95%

关联疾病

疾病名称 别名
Gastritis

Acute Gastric Mucosal Erosion

Erosive Gastritis

Erosive Gastropathy

Gastritis Erosive

Idiopathic Erosive/Hemorrhagic Gastritis

Inflammation Of Gastric Mucosa

Gastroduodenitis

Gastritis Nos

Noninfectious Gastroenteritis

Nonbacterial Gastroenteritis Of Infant

Acute Gastric Infection

Acute Simple Gastritis

Chronic Antral Gastritis

Chronic Fundal Gastritis

Chronic Simple Gastritis

Acute Gastroduodenitis

Acute Antral Gastritis

Acute Erosive Gastritis

Bile Reflux Gastritis

Gastritis Due To Biliary Reflux

Atrophic Gastritis

Gastritis, Atrophic

Gastric Atrophy

Gastritis Atrophic

Alcoholic Gastritis

Alcoholic Gastritis, With Hemorrhage

Alcoholic Gastritis, Without Mention Of Hemorrhage

Alcohol Gastritis

Etoh Gastritis

Febrile Seizures, Familial, 1

FEB1

Convulsions, Familial Febrile, 1

Familial Febrile Seizures 1

Familial Febrile Convulsions 1

Papillary Adenofibroma
Autoimmune Gastritis
Gastric Ulcer

Stomach Ulcer

Acute Gastric Ulcer With Haemorrhage And Perforation

Acute Gastric Ulcer With Hemorrhage And Obstruction

Acute Gastric Ulcer With Hemorrhage And Perforation

Acute Gastric Ulcer With Hemorrhage And Perforation, With Obstruction

Acute Gastric Ulcer With Hemorrhage And Perforation, Without Mention Of Obstruction

Acute Gastric Ulcer With Hemorrhage And With Perforation But Without Obstruction

Acute Gastric Ulcer With Hemorrhage, With Obstruction

Acute Gastric Ulcer With Hemorrhage, With Perforation And With Obstruction

Acute Gastric Ulcer With Perforation

Acute Gastric Ulcer With Perforation And Obstruction

Acute Gastric Ulcer With Perforation, With Obstruction

Acute Gastric Ulcer Without Hemorrhage And Without Perforation

Acute Gastric Ulcer Without Hemorrhage, Without Perforation And Without Obstruction

Acute Gastric Ulcer Without Mention Of Hemorrhage Or Perforation, Without Mention Of Obstruction

Bleeding Acute Gastric Ulcer

Chronic Gastric Ulcer Without Hemorrhage And Without Perforation

Chronic Gastric Ulcer Without Hemorrhage And Without Perforation But With Obstruction

Chronic Gastric Ulcer Without Mention Of Hemorrhage Or Perforation, With Obstruction

Gastric Ulcers

Cushings Ulcer

Cushing'S Ulcer Of Stomach

Peptic Ulcer Of Stomach

Mucosal Defect Of The Stomach

Gastric Cancer

Stomach Cancer

Gastric Carcinoma

Stomach Carcinoma

Gastric Cancer, Somatic

Gastric Neoplasm

Carcinoma Of Stomach

Stomach Neoplasms

Malignant Neoplasm Of Stomach

Gastric Cancer Risk After H. Pylori Infection

Cancer Of The Stomach

Adult Stomach Cancer

Adult Stomach Carcinoma

GASC

Gastric Cancer Intestinal

Gastric Cancers

Gastric Carcinomas

Cancer, Gastric

Stomach Neoplasm

Malignant Neoplasm Of Body Of Stomach

Malignant Tumor Of Lesser Curve Of Stomach

Gastrocarcinoma Of Unspecified Site

Leather Bottle Stomach

Carcinoma Of Fundus Of Stomach

Cancer Of Fundus Of Stomach

Primary Malignant Neoplasm Of Body Of Stomach

Cancer Of Body Of Stomach

Primary Malignant Neoplasm Of Pyloric Antrum

Pyloric Antrum Cancer

Malignant Tumour Of Stomach

Colitis
Inflammatory Bowel Disease

Inflammatory Bowel Diseases

Bowel Disease, Inflammatory

Barrett Esophagus

Barrett'S Esophagus

Barrett Esophagus/Esophageal Adenocarcinoma

Barrett Metaplasia

Barrett'S Ulcer Of Esophagus

Ulcerative Esophagitis

Barrett'S Esophagus With Esophagitis

Barrett'S Oesophagus

Barretts Syndrome

Barrett Syndrome

BE

Peptic Ulcer Of Esophagus

Adenocarcinoma Of Esophagus

Gastritis, Familial Giant Hypertrophic

Menetrier Disease

Gastric Mucosal Hypertrophy

Giant Hypertrophic Gastritis

Hypertrophic Gastropathy

Gastritis, Hypertrophic

Familial Giant Hypertrophic Gastritis

Giant Rugal Hypertrophy Of Stomach

Hypertrophic Gastritis

Gastroenteropathy, Protein Losing

Giant Hypertrophic Gastropathy

Giant Hypertrophy Of The Gastric Mucosa

Hypoproteinemic Hypertrophic Gastropathy

Menetrier'S Disease

Giant Hypertrophic Hypersecretory Gastritis

Gastrointestinal Adenoma

Gi Adenoma

Digestive System Adenoma

Microinvasive Gastric Cancer

Early Gastric Cancer

Surface Gastric Cancer

Pancreatic Cancer

Pancreatic Carcinoma

Carcinoma Of Pancreas

Familial Pancreatic Carcinoma

Pancreatic Neoplasm

Pancreatic Carcinoma, Familial

Malignant Neoplasm Of Pancreas

Pancreatic Acinar Carcinoma

Pancreatic Tumor

Familial Pancreatic Cancer

Neoplasm Of The Pancreas

Cancer Of The Pancreas

Pancreatic Carcinoma, Somatic

Pancreatic Cancer, Somatic

Ca Body Of Pancreas

Ca Head Of Pancreas

Ca Tail Of Pancreas

Malignant Neoplasm Of Body Of Pancreas

Malignant Neoplasm Of Head Of Pancreas

Malignant Neoplasm Of Tail Of Pancreas

Pancreas Neoplasm

Exocrine Cancer

Exocrine Pancreas Carcinoma

Hereditary Pancreatic Cancer

Hereditary Pancreatic Carcinoma

PNCA

Pancreatic Cancer, Susceptibility To

Carcinoma Of Head Of Pancreas

Pancreatic Neoplasms

Pancreatic Tumors

Cancer, Pancreatic

Cancer Of Pancreas

Mixed Islet Cell With Exocrine Carcinoma Of Unspecified Site

Diffuse Gastric Cancer

Hereditary Diffuse Gastric Adenocarcinoma

Hereditary Diffuse Gastric Cancer

Signet Cell Adenocarcinoma

Signet Ring Cell Carcinoma

Signet Ring Cell Gastric Carcinoma

Signet Ring Gastric Carcinoma

Fdgc

Familial Diffuse Cancer Of Stomach

Familial Diffuse Gastric Cancer

Gastric Cancer, Familial Diffuse

Gastric Cancer, Hereditary Diffuse

Hdgc

Hereditary Diffuse Cancer Of Stomach

Diffuse Gastric Cancer Syndrome

Cancer, Gastric, Diffuse

Carcinoma, Signet Ring Cell

Gastric Signet Ring Carcinoma

Retinitis Pigmentosa 39

RP39

Retinitis Pigmentosa, Type 39

疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

直系同源

种属 基因名 来源 基因 ID
Bos taurus TFF2 VGNC VGNC:35791
Canis familiaris TFF2 VGNC VGNC:47297
Mus musculus TFF2 MGD MGI:1306805
Felis catus TFF2 VGNC VGNC:66120
Macaca mulatta TFF2 VGNC VGNC:78327
Rattus norvegicus TFF2 RGD RGD:620709
Others TFF2 NCBI