2. 重组蛋白
  3. CD Antigens Biotinylated Proteins
  4. Endothelial cell CD Proteins
  5. TFR-1/CD71
  6. TFRC 蛋白, Cynomolgus (Biotinylated, HEK293, His)

TFRC 蛋白, Cynomolgus (Biotinylated, HEK293, His)

目录号: HY-P78904
产品使用指南 技术支持

TFRC 蛋白通过触发配体占据的转铁蛋白受体的受体介导的内吞作用来介导铁的吸收，然后进行酸化和铁释放。它对于红细胞和神经系统的发育以及维持铁平衡至关重要。TFRC 蛋白, Cynomolgus (Biotinylated, HEK293, His) 是重组的 TFRC 蛋白，由 HEK293 表达，带有 N-His 标签。TFRC 蛋白, Cynomolgus (Biotinylated, HEK293, His) 全长 672 个氨基酸，分子量为 70-90 kDa。

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描述

TFRC proteins mediate iron uptake by triggering receptor-mediated endocytosis of ligand-occupied transferrin receptors, followed by acidification and iron release. It is essential for red blood cell and nervous system development, and for maintaining iron balance. TFRC Protein, Cynomolgus (Biotinylated, HEK293, His) is the recombinant cynomolgus-derived TFRC protein, expressed by HEK293 , with N-His labeled tag. The total length of TFRC Protein, Cynomolgus (Biotinylated, HEK293, His) is 672 a.a., with molecular weight of 70-90 kDa.
研究背景

TFRC 蛋白通过受体介导的将配体占据的转铁蛋白受体内吞到专门的内体中来协调细胞对铁的摄取。该过程涉及内体酸化，导致铁的释放，然后将脱铁转铁蛋白-受体复合物再循环到细胞表面，pH值恢复到中性，同时脱铁转铁蛋白对其受体的亲和力丧失。TFRC 对于红细胞和神经系统的发育至关重要，在铁稳态中发挥着关键作用。除了与铁相关的功能外，TFRC 还充当脂质传感器，通过调节 JNK 通路的激活来调节线粒体融合。此外，TFRC 通过二硫键形成同二聚体，为其多方面参与细胞过程增添了另一层。
种属

Cynomolgus
表达系统

HEK293
标签

N-His
蛋白编号

G8F602 (C89-F760)
基因 ID

/
蛋白结构
N-term
His
TFRC (C89-F760)
Accession # G8F602
C-term
同用名
CD71; TFRC; TFR; sTfR; TfR1; Trfr; T9; p90
分子量

70-90 kDa
纯度

Greater than 95% as determined by reducing SDS-PAGE.
内毒素含量

<1 EU/μg, determined by LAL method.
文件资料
产品使用指南 (1213 KB)

TFRC Protein, Cynomolgus (Biotinylated, HEK293, His) 相关分类

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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  • 重组蛋白稀释计算器

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The reconstitution calculator equation

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration
= ÷

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2

The specific activity calculator equation

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)
Unit/mg = 106 ÷ ng/mL

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