TIM-1/KIM-1/HAVCR 蛋白, Rat (HEK293, His)

TIM-1/KIM-1/HAVCR protein is a phosphatidylserine receptor that plays a crucial regulatory role in regulatory B cells, affecting their generation, expansion and inhibitory functions. It acts as a ligand for P-selectin/SELPLG and controls activated T cell trafficking during inflammatory responses. TIM-1/KIM-1/HAVCR Protein, Rat (HEK293, His) is the recombinant rat-derived TIM-1/KIM-1/HAVCR protein, expressed by HEK293 , with N-His labeled tag. The total length of TIM-1/KIM-1/HAVCR Protein, Rat (HEK293, His) is 221 a.a., with molecular weight of ~55-65 kDa.

TIM-1/KIM-1/HAVCR 蛋白作为磷脂酰丝氨酸受体，在调节 B 细胞的稳态中发挥着至关重要的功能作用，影响其生成、扩增和抑制功能。此外，作为 P-选择素/SELPLG 的配体，它在炎症反应过程中活化 T 细胞的运输中发挥特殊作用，特别是控制发炎中枢神经系统中 T 细胞的积累并影响自身免疫性疾病的诱导。TIM-1/KIM-1/HAVCR 还调节各种抗炎细胞因子和共抑制配体（包括 IL10）的表达，充当 T 细胞增殖的调节剂。此外，它可能在肾脏损伤和修复中发挥作用。与 STAM 和 SELPLG 的相互作用有助于 TIM-1/KIM-1/HAVCR 蛋白的多方面调节功能。

Rat

HEK293

N-His

O54947/NP_775172.1 (S18-V238)

286934  [NCBI]

SVDSYEVVKGVVGHPVTIPCTYSTRGGITTTCWGRGQCPYSSCQNILIWTNGYQVTYRSSGRYNIKGRISEGDVSLTIENSVDSDSGLYCCRVEIPGWFNDQKMTFSLEVKPEIPTSPPTRPTTTRPTTTRPTTISTRSTHVPTSTRVSTSTPTPEQTQTHKPEITTFYAHETTAEVTETPSYTPADWNGTVTSSEEAWNNHTVRIPLRKPQRNPTKGFYV

Approximately 55-65 kDa

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  Greater than 95% as determined by reducing SDS-PAGE. It migrates as an approximately 55-65 kDa band in SDS-PAGE under reducing conditions due to glycosylation.

无菌粉末

Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4.

<1 EU/μg, determined by LAL method.

It is not recommended to reconstitute to a concentration less than 100 μg/mL in ddH₂O. For long term storage it is recommended to add a carrier protein (0.1% BSA, 5% HSA, 10% FBS or 5% Trehalose).

Stored at -20°C for 2 years. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.

Room temperature in continental US; may vary elsewhere.