TIM-3/HAVCR2 蛋白, Marmoset (HEK293, His)

TIM-3/HAVCR2 Protein is a transmembrane glycoprotein of the TIM family of immune regulating molecules and plays an important role in the Th1-mediated immune response^[1]. TIM-3/HAVCR2 Protein, Marmoset (HEK293, His) is the recombinant Marmoset-derived TIM-3/HAVCR2 protein, expressed by HEK293 , with C-6*His labeled tag. The total length of TIM-3/HAVCR2 Protein, Marmoset (HEK293, His) is 170 a.a., with molecular weight of 30-45 kDa.

TIM-3/HAVCR2 蛋白是 T 淋巴细胞（CD4⁺ 和 CD8⁺ T 细胞）、其他淋巴细胞（如 NK 细胞）、骨髓细胞（单核细胞、巨噬细胞、DC、肥大细胞）或不同肿瘤类型中的各种细胞。TIM-3/HAVCR2 蛋白是一种免疫检查点，与程序性细胞死亡蛋白 1 (PD-1) 和淋巴细胞激活基因 3 蛋白 (LAG3) 等其他抑制性受体一起介导 CD8+ T 细胞增殖耗竭以及细胞因子的分泌，例如 TNF-α、IFN-γ 和 IL-2^[2][3]。TIM-3/HAVCR2 蛋白 还被证明是一种 CD4+ Th1 特异性细胞表面蛋白，可调节巨噬细胞活化、调节细胞因子的产生并增强小鼠实验性自身免疫性脑脊髓炎的严重程度^[1]。

Marmoset

HEK293

C-6*His

F7I881 (E21-I190)

100399869  [NCBI]

EEYIVEVGQNAYLPCFYTLDTPGNLVPVCWGKGACPVFECGDVVLRTDERDVSYRTSSRYWLNGDFHKGNVTLAIGNVTLEDSGIYCCRVQIPGIMNDKKFNLKLVIKPAKVTPAPTLPRDSTPAFPRMLTTEDHGPAETQTLEILHDKNLTQLSTLANELQDAGTTIRI

30-45 kDa

Greater than 95% as determined by reducing SDS-PAGE.

无菌粉末.

Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4.

<1 EU/μg, determined by LAL method.

It is not recommended to reconstitute to a concentration less than 100 μg/mL in ddH₂O. For long term storage it is recommended to add a carrier protein (0.1% BSA, 5% HSA, 10% FBS or 5% Trehalose).

Stored at -20°C for 2 years. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.

Room temperature in continental US; may vary elsewhere.