TIMP-1 蛋白, Rat (HEK293)

The IgG3 Fc protein is the constant region of an immunoglobulin heavy chain that acts as a receptor for a specific antigen. TIMP-1 Protein, Rat (HEK293) is the recombinant rat-derived TIMP-1 protein, expressed by HEK293 , with tag free. The total length of TIMP-1 Protein, Rat (HEK293) is 217 a.a., with molecular weight of ~28 kDa.

免疫球蛋白重链的恒定区（称为抗体）代表 B 淋巴细胞产生的膜结合或分泌糖蛋白。在体液免疫的识别阶段，这些膜结合的免疫球蛋白充当受体，在与特定抗原结合后，触发 B 淋巴细胞克隆扩增并分化为分泌免疫球蛋白的浆细胞。分泌的免疫球蛋白在体液免疫的效应阶段发挥着关键作用，导致结合抗原的消除。抗原结合位点由一条重链的可变结构域与其相关轻链的可变结构域一起形成，导致每种免疫球蛋白具有两个对特定抗原具有显着亲和力的抗原结合位点。可变结构域经历 V-(D)-J 重排和随后的体细胞超突变，从而在暴露和选择后实现特定抗原的亲和力成熟。免疫球蛋白由两条相同的重链和两条相同的轻链组成，通过二硫键连接在一起。

Measured by its ability to inhibit human MMP2 cleavage of a fluorogenic peptide substrate MCA-PLGLDPA-AR-NH2 and the IC₅₀ value is approximately <4 nM.

Rat

HEK293

Tag Free

P30120/NP_446271.1 (C24-A217)

116510

ASTKGPSVFPLAPCSRSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYTCNVNHKPSNTKVDKRVELKTPLGDTTHTCPRCPEPKSCDTPPPCPRCPEPKSCDTPPPCPRCPEPKSCDTPPPCPRCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVQFKWYVDGVEVHNA

Approximately 28 kDa

Greater than 95% as determined by reducing SDS-PAGE

无菌粉末.

Lyophilized from a 0.2 μm filtered solution of 50 mM Tris, 100 mM NaCl, pH 7.0. Normally 5 % - 8 % trehalose, mannitol and 0.01% Tween 80 are added as protectants before lyophilization.

<1 EU/μg, determined by LAL method.

It is not recommended to reconstitute to a concentration less than 100 μg/mL in ddH₂O.

Stored at -20°C for 2 years. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.

Room temperature in continental US; may vary elsewhere.