TMED1 蛋白, Human (HEK293, Fc)

The TMED1 protein may facilitate vesicular protein trafficking in the early secretory pathway, acting as a cargo receptor on the luminal side to incorporate secretory cargo into transport vesicles. It is involved in the formation of the vesicle shell on the cytoplasmic side and positively affects IL-33-mediated IL-8 and IL-6 production by interacting with IL1RL1. TMED1 Protein, Human (HEK293, Fc) is the recombinant human-derived TMED1 protein, expressed by HEK293 , with C-hFc labeled tag.

TMED1 蛋白可能在囊泡蛋白运输中发挥作用，特别是在早期分泌途径中。它可以充当腔侧的货物受体，以促进分泌性货物分子掺入运输囊泡中，并且它还涉及细胞质侧的囊泡外壳形成。此外，TMED1 通过与白细胞介素 33 受体 IL1RL1 相互作用，对 IL-33 介导的 IL-8 和 IL-6 产生产生积极影响。此外，它还通过与 RNF26 的相互作用，通过 cGAS-STING 途径参与先天免疫信号的调节。TMED1 在内质网、内质网-高尔基体中间室和顺式高尔基体网络中形成同二聚体。它与 IL1RL1 和 RNF26 相互作用，后者的相互作用对于通过 cGAS-STING 途径调节先天免疫信号传导特别重要。

Human

HEK293

C-hFc

Q13445 (A24-N194)

11018  [NCBI]

AGPPPIQDGEFTFLLPAGRKQCFYQSAPANASLETEYQVIGGAGLDVDFTLESPQGVLLVSESRKADGVHTVEPTEAGDYKLCFDNSFSTISEKLVFFELIFDSLQDDEEVEGWAEAVEPEEMLDVKMEDIKESIETMRTRLERSIQMLTLLRAFEARDRNLQEGNLERVN

55-65 kDa

Greater than 90% as determined by reducing SDS-PAGE.

<1 EU/μg, determined by LAL method.