TPBG/5T4 蛋白, Cynomolgus (HEK293, His)

TPBG/5T4 protein blocks Wnt3a-dependent LRP6 internalization by indirectly interacting with LRP6, thereby potentially inhibiting Wnt/β-catenin signaling. This unique mechanism suggests that TPBG/5T4 plays a crucial role in regulating the Wnt/β-catenin pathway by disrupting LRP6 internalization and affecting downstream signaling. TPBG/5T4 Protein, Cynomolgus (HEK293, His) is the recombinant cynomolgus-derived TPBG/5T4 protein, expressed by HEK293 , with C-6*His labeled tag. The total length of TPBG/5T4 Protein, Cynomolgus (HEK293, His) is 321 a.a., with molecular weight of 55-80 kDa.

TPBG/5T4 蛋白是 Wnt/β-连环蛋白信号传导的潜在抑制剂，通过与 LRP6 间接相互作用并阻断 Wnt3a 依赖性 LRP6 内化来发挥作用。这种独特的机制表明，TPBG/5T4 通过破坏 LRP6 的内化过程，从而影响下游信号转导事件，在调节 Wnt/β-catenin 通路中发挥着至关重要的作用。对 TPBG/5T4 功能的深入了解强调了其在调节与 Wnt/β-连环蛋白信号传导相关的复杂分子动力学方面的重要性，为细胞调节过程中的治疗探索提供了潜在途径。

Cynomolgus

HEK293

C-6*His

Q4R8Y9 (T35-S355)

102132149  [NCBI]

TSSASSSSSSAPFLASAASAQPPLPDQCPALCECSEAARTVKCVNRNLTEVPTDLPLYVRNLFLTGNQLAVLPAGAFARRPPLAELAALNLSGSRLDEVRGGAFEHLPSLRQLDLSHNPLAYLSPFAFSGSNASISAPSPLVELILNHIVPPDDKRQNRSFEGMVAAALVAGRALQGLHLLELASNHFLYLPRDVLAQLPSLRYLDLSNNSLVSLTYVSFRNLTHLESLHLEDNALKVLHNGTLAELQGLPHVRVFLDNNPWVCDCHMADMVTWLKQTGVVQGKDRLTCAFPEKMRNRVLLELNSADLDCDPILPPSLQTS

55-80 kDa

Greater than 95% as determined by reducing SDS-PAGE

无菌粉末.

Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4.

<1 EU/μg, determined by LAL method.

It is not recommended to reconstitute to a concentration less than 100 μg/mL in ddH₂O. For long term storage it is recommended to add a carrier protein (0.1% BSA, 5% HSA, 10% FBS or 5% Trehalose).

Stored at -20°C for 2 years. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.

Room temperature in continental US; may vary elsewhere.