TPH2 蛋白, Human (His)

TPH2 Protein, an isozyme of tryptophan hydroxylase, is a member of the pterin-dependent aromatic acid hydroxylase family. TPH2 is selectively expressed only in the serotonergic neurons of the raphe nuclei and is a rate-limiting enzyme in the brain serotonin synthesis pathway. TPH2 plays a more prominent role in the 5-HT synthesis in the brain. Moreover, it is a key factor in maintaining normal serotonin transfer in the central nervous system. TPH2 Protein, Human (His) is the recombinant human-derived TPH2 protein, expressed by E. coli , with N-6*His labeled tag.

色氨酸 5-羟化酶 2 (TPH2) 是色氨酸羟化酶的同工酶，是蝶呤依赖性芳香酸羟化酶家族的成员。TPH2 仅在中缝核的血清素能神经元中选择性表达，是大脑血清素合成途径中的限速酶。TPH2 在大脑中的 5-HT 合成中起着更重要的作用。5HT与许多中枢神经活动存在因果关系，并且它在外周组织中具有多种功能，包括维持血管张力和肠道蠕动。TPH2 在焦虑、攻击性和抑郁相关的人格特征以及认知控制和情绪调节缺陷疾病的发病机制中发挥着重要作用。此外，它是维持中枢神经系统正常血清素转移的关键因素。TPH2亚型在大脑中特异性表达^[1][2]。

Human

E. coli

N-6*His

Q8IWU9-1 (M1-I490)

121278

MQPAMMMFSSKYWARRGFSLDSAVPEEHQLLGSSTLNKPNSGKNDDKGNKGSSKREAATESGKTAVVFSLKNEVGGLVKALRLFQEKRVNMVHIESRKSRRRSSEVEIFVDCECGKTEFNELIQLLKFQTTIVTLNPPENIWTEEEELEDVPWFPRKISELDKCSHRVLMYGSELDADHPGFKDNVYRQRRKYFVDVAMGYKYGQPIPRVEYTEEETKTWGVVFRELSKLYPTHACREYLKNFPLLTKYCGYREDNVPQLEDVSMFLKERSGFTVRPVAGYLSPRDFLAGLAYRVFHCTQYIRHGSDPLYTPEPDTCHELLGHVPLLADPKFAQFSQEIGLASLGASDEDVQKLATCYFFTIEFGLCKQEGQLRAYGAGLLSSIGELKHALSDKACVKAFDPKTTCLQECLITTFQEAYFVSESFEEAKEKMRDFAKSITRPFSVYFNPYTQSIEILKDTRSIENVVQDLRSDLNTVCDALNKMNQYLGI

Approximately 60.0 kDa

Greater than 90% as determined by reducing SDS-PAGE.

<1 EU/μg, determined by LAL method.