1. 重组蛋白
  2. Receptor Proteins
  3. TREML2 蛋白, Mouse (HEK293, His)

TREML2 蛋白, Mouse (HEK293, His)

目录号: HY-P71384
产品使用指南

TREML2 蛋白作为 SEMA6A 的细胞表面受体,影响小脑发育中的关键细胞间信号传导。它调节颗粒细胞迁移,协调肌动蛋白细胞骨架重组,并对中枢神经系统的轴突引导做出重大贡献。TREML2 蛋白, Mouse (HEK293, His) 是重组的 TREML2 蛋白,由 HEK293 表达,带有 C-6*His 标签。TREML2 蛋白, Mouse (HEK293, His) 全长 246 个氨基酸,分子量为 58-62 kDa。

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描述

TREML2 protein acts as a cell surface receptor for SEMA6A and affects key intercellular signaling in cerebellar development. It regulates granule cell migration, coordinates actin cytoskeletal reorganization, and contributes significantly to axonal guidance in the central nervous system. TREML2 Protein, Mouse (HEK293, His) is the recombinant mouse-derived TREML2 protein, expressed by HEK293 , with C-6*His labeled tag. The total length of TREML2 Protein, Mouse (HEK293, His) is 246 a.a., with molecular weight of 58-62 kDa.

研究背景

Semaphorin-6A/SEMA6A 作为 PLXNA2 的细胞表面受体,在细胞间信号传导中发挥着至关重要的作用,特别是在小脑发育过程中颗粒细胞迁移的调节中。它协调肌动蛋白细胞骨架的重组,并作为发育中的中枢神经系统内轴突引导的重要贡献者,对迁移的颗粒神经元表现出排斥作用。此外,SEMA6A 还参与将交感神经轴突引导至交感神经链并控制交感神经靶标神经支配的时间序列。在微生物感染的情况下,SEMA6A 作为血管系统中 P.sordellii 毒素 TcsL 的受体,强调了其在发育过程和对外部刺激的反应中的不同作用。

种属

Mouse

表达系统

HEK293

标签

C-6*His

蛋白编号

Q2LA85 (H25-A270)

基因 ID
蛋白结构
N-term
TREML2 (H25-A270)
Accession # Q2LA85
6*His
C-term
同用名
Trem-like transcript 2 protein; TLT-2; Triggering receptor expressed on myeloid cells-like protein 2; TREML2; TLT2
氨基酸序列

HSNENLYRKVWRREGETLSVQCSYKNRRNLVEAKSWCKVKKKKCDHNFTRSWVRGPSYSLRDDAKVKVVRITMEALRVQDSGRYWCMRNTAGHFYPLVGFQLEVYPALTTERNVPHTHLTNTPMDGFVTTGQVHISDPHAPFTSDVTMFTSEVTMFTSGLLTLASGTTTPTPVTGYSFIDTSGTVTEPERNTESQPATLSPSNARSFSADPVTTSTMSRHQSSSLSTTGTCHPLTPNRSQETYIPA

分子量

58-62 kDa

纯度

Greater than 95% as determined by reducing SDS-PAGE.

内毒素含量

<1 EU/μg, determined by LAL method.

文件资料

TREML2 Protein, Mouse (HEK293, His) 相关分类

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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The reconstitution calculator equation

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration
= ÷

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2

The specific activity calculator equation

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)
Unit/mg = 106 ÷ ng/mL

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产品名称:
TREML2 Protein, Mouse (HEK293, His)
目录号:
HY-P71384
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