TrkA 蛋白, Human (HEK293, His)

Pentraxin 3/TSG-14 protein is a multifunctional protein that plays a role in immune response and inflammation. It is involved in the recognition and clearance of pathogens, as well as regulation of inflammatory processes. Dysregulation of Pentraxin 3/TSG-14 protein has been associated with various diseases, including cardiovascular disorders and infections. Targeting Pentraxin 3/TSG-14 protein may hold therapeutic potential in these conditions. TrkA Protein, Human (HEK293, His) is the recombinant human-derived TrkA protein, expressed by HEK293 , with N-His labeled tag. The total length of TrkA Protein, Human (HEK293, His) is 220 a.a., with molecular weight of 35-60 kDa.

TrkA 蛋白是神经营养酪氨酸激酶受体 (NTKR) 家族的成员，编码一种膜结合受体，在与神经营养蛋白结合后，启动其自身和 MAPK 通路成员的磷酸化。这种激酶的存在促进细胞分化，并可能在指定感觉神经元亚型中发挥作用。该基因的突变与先天性疼痛不敏感、无汗症、自残行为、认知障碍和癌症有关。该基因的几种替代转录剪接变体已被鉴定，但迄今为止仅对三种进行了表征。该基因表现出偏表达，在肾上腺 (RPKM 3.7)、睾丸 (RPKM 1.0) 和 10 个其他组织中检测到较高水平，表明其在多个器官的各种生理环境中具有潜在意义。

Measured by its ability to inhibit NGF-induced proliferation of TF-1 human erythroleukemic cells. The ED₅₀ for this effect is 0.06643 μg/mL, corresponding to a specific activity is 1.51×10^4 units/mg.

Human

HEK293

N-His

NP_002520.2 (P194-E413)

4914  [NCBI]

PTLKVQVPNASVDVGDDVLLRCQVEGRGLEQAGWILTELEQSATVMKSGGLPSLGLTLANVTSDLNRKNVTCWAENDVGRAEVSVQVNVSFPASVQLHTAVEMHHWCIPFSVDGQPAPSLRWLFNGSVLNETSFIFTEFLEPAANETVRHGCLRLNQPTHVNNGNYTLLAANPFGQASASIMAAFMDNPFEFNPEDPIPVSFSPVDTNSTSGDPVEKKDE

35-60 kDa

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  Measured by its ability to inhibit NGF-induced proliferation of TF-1 human erythroleukemic cells. The ED₅₀ for this effect is 0.06643 μg/mL, corresponding to a specific activity is 1.51×10₄ units/mg.

无菌粉末.

Lyophilized from a 0.2 μm filtered solution of 20 mM PB, 150 mM NaCl, pH 7.4.

<1 EU/μg, determined by LAL method.

It is not recommended to reconstitute to a concentration less than 100 μg/mL in ddH₂O.

Stored at -20°C for 2 years. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.

Room temperature in continental US; may vary elsewhere.