2. 重组蛋白
  3. Receptor Proteins Enzymes & Regulators
  4. Receptor Tyrosine Kinases Protein Tyrosine Kinases
  5. Trk Receptors TrkB
  6. TrkB 蛋白, Canine (HEK293, Fc)

TrkB 蛋白, Canine (HEK293, Fc)

目录号: HY-P73576
产品使用指南

TrkB 蛋白是一种神经营养因子受体，是原肌球蛋白受体激酶家族的成员，对脑源性神经营养因子（BDNF）具有高亲和力，在神经元的多种生理功能中发挥作用，包括细胞存活和分化。TrkB 蛋白 具有致癌活性。TrkB 蛋白, Canine (HEK293, Fc) 是重组的 TrkB 蛋白，由 HEK293 表达，带有 C-hFc 标签。

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100 μg   询价  

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描述

TrkB Protein is a neurotrophic factor receptor and a member of the tropomyosin receptor kinase family. TrkB Protein has high affinity for brain-derived neurotrophic factor (BDNF) and plays a role in various physiological functions of neurons, including cell survival and differentiation. TrkB Protein has carcinogenic activity. TrkB Protein, Canine (HEK293, Fc) is the recombinant canine-derived TrkB protein, expressed by HEK293 , with C-hFc labeled tag.
研究背景

TrkB Protein 对脑源性神经营养因子（BDNF）具有高亲和力，在神经元的多种生理功能中发挥作用，包括细胞存活和分化[1]。
TrkB Protein 参与与许多癌细胞系迁移和侵袭性增加相关的上皮到间充质转化[3]。
TrkB Protein 过表达或融合引起的异常激活可促进多种类型神经源性肿瘤的肿瘤发生、进展和对治疗的耐药性[5]。
TrkB Protein 的失调与许多疾病的发病机制有关，如神经行性退变疾病、血管生成、肺腺癌和胃癌[2][3][4]。
种属

Canine
表达系统

HEK293
标签

C-hFc
蛋白编号

A0A8C0LGP8/XP_541264.2 (C32-H430)
基因 ID
蛋白结构
N-term
TrkB (C32-H430)
Accession # A0A8C0LGP8/XP_541264.2
hFc
C-term
同用名
BDNF/NT-3 Growth Factors Receptor; Trk-B; NTRK2; TRKB
分子量

Approximately 71.2 kDa
纯度

Greater than 95% as determined by reducing SDS-PAGE.
内毒素含量

<1 EU/μg, determined by LAL method.
文件资料
产品使用指南 (1213 KB)

TrkB Protein, Canine (HEK293, Fc) 相关分类

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

  • 复溶计算器

  • 重组蛋白稀释计算器

  • 比活力计算器

The reconstitution calculator equation

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration
= ÷

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2

The specific activity calculator equation

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)
Unit/mg = 106 ÷ ng/mL

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