TSLP 蛋白, Cynomolgus (His)

Thymic stromal lymphopoietin (TSLP) is a hemopoietic cytokine proposed to signal through a heterodimeric receptor complex composed of the thymic stromal lymphopoietin receptor and the IL-7R alpha chain. TSLP mainly impacts myeloid cells and promotes T helper type 2 (TH2) cell responses associated with immunity in various inflammatory diseases, including asthma, allergic inflammation and chronic obstructive pulmonary disease. TSLP Protein, Cynomolgus (His) is the recombinant cynomolgus-derived TSLP protein, expressed by E. coli , with C-6*His labeled tag and Q37E mutation. The total length of TSLP Protein, Cynomolgus (His) is 131 a.a., with molecular weight of ~16.0 kDa.

胸腺基质淋巴细胞生成素 (TSLP) 是一种造血细胞因子，通过由胸腺基质淋巴细胞生成素受体和 IL-7R α 链组成的异二聚体受体复合物发出信号。 TSLP主要影响骨髓细胞，诱导单核细胞释放T细胞吸引趋化因子，并促进CD11c(+)树突状细胞的成熟。 TSLP 可促进与多种炎症性疾病（包括哮喘、过敏性炎症和慢性阻塞性肺病）的免疫相关的 2 型辅助 T (TH2) 细胞反应，因此 TSLP 被认为是治疗此类疾病的潜在治疗靶点。 TSLP 基因的选择性剪接产生多种亚型，较短的（主要）亚型是一种抗菌蛋白，对 B.B. 具有抗菌和抗真菌活性。蜡状芽孢杆菌、大肠杆菌、粪肠球菌、轻链球菌、表皮葡萄球菌和C.白色念珠菌^[1][2][3][4]。

Cynomolgus

E. coli

C-6*His

XP_005557555.1 (Y29-Q159, Q37E)

102119254  [NCBI]

YDFTNCDFEKIEADYLRTISKDLITYMSGTKSTDFNNTVSCSNRPHCLTEIQSLTFNPTPRCASLAKEMFARKTKATLALWCPGYSETQINATQAMKKRRKRKVTTNKCLEQVSQLLGLWRRFIRTLLKKQ

Approximately 16.0 kDa

Greater than 95% as determined by reducing SDS-PAGE.

<1 EU/μg, determined by LAL method.