UFC1 蛋白, Human (Sf9, His, Strep)

The UFC1 protein catalyzes the second step of ufmylation, accepting UFM1 from UBA5 and forming an intermediate with UFM1. Ufmylation is involved in reticulophagy and interacts with UBA5, UFL1, and UFM1. It also interacts with KIRREL3. UFC1 Protein, Human (Sf9, His, Strep) is the recombinant human-derived UFC1 protein, expressed by Sf9 insect cells , with N-Strep, N-8*His labeled tag. The total length of UFC1 Protein, Human (Sf9, His, Strep) is 166 a.a., .

UFC1 作为一种 E1 样酶，在 ufmylation（一种特定的翻译后修饰过程）的第二步中发挥着至关重要的作用。该酶接受来自 E1 酶 UBA5 的 UFM1，通过硫酯键与 UFM1 形成中间体。值得注意的是，ufmylation 与内质网应激引发的网状吞噬（ER-phagy）有关。UFC1 与包括 UBA5 在内的主要合作伙伴进行互动，强调其在 ufmylation 途径中的复杂参与。此外，UFC1 与 UFL1 和 KIRREL3 相互作用，强调了它在 ufmylation 之外的多种细胞过程中的潜在作用。这些相互作用强调了 UFC1 在协调细胞对压力的反应和维持细胞稳态方面的重要性。

Human

Sf9 insect cells

N-Strep;N-8*His

Q9Y3C8 (A2-Q167)

51506

Approximately 22.5 kDa

Greater than 90% as determined by reducing SDS-PAGE.

溶液

Supplied as a 0.22 μm filtered solution of 50 mM HEPES, pH 7.5, 200 mM NaCl, 20% glycerol, 1 mM DTT.

<1 EU/μg, determined by LAL method.

Please use rapid thawing with running water to thaw the protein.

Stored at -80°C for 1 year. It is stable at -20°C for 3 months after opening. It is recommended to freeze aliquots at -80°C for extended storage. Avoid repeated freeze-thaw cycles.

Shipping with dry ice.