UGRP1 蛋白, Human

UGRP1, a secreted cytokine-like protein, interacts with pathogens (L.monocytogenes, P.aeruginosa, yeast) and binds to MARCO. It strongly inhibits PLA2G1B activity, exerting anti-inflammatory and anti-fibrotic effects in the lung. UGRP1 may contribute to fetal lung development, inhibits FSH and LH production in the pituitary, and interacts with APOA1. Structurally, UGRP1 exists as a homodimer, with diverse physiological roles. UGRP1 Protein, Human is the recombinant human-derived UGRP1 protein, expressed by E. coli , with tag free. The total length of UGRP1 Protein, Human is 72 a.a., with molecular weight of ~6 & 7 kDa, respectively.

UGRP1 是一种分泌性细胞因子样蛋白，具有广泛的功能。它与清道夫受体 MARCO 结合，并表现出与多种病原体的结合能力，包括革兰氏阳性细菌单核细胞增多性李斯特菌、革兰氏阴性细菌铜绿假单胞菌和酵母。此外，UGRP1 强烈抑制磷脂酶 A2 (PLA2G1B) 活性，并似乎在呼吸道上皮细胞中发挥抗炎作用。此外，它在肺部具有抗纤维化活性，可能在胎儿肺部发育和成熟中发挥作用，在肺部发育的早期阶段积极促进分支形态发生。在垂体中，UGRP1 可能会抑制卵泡刺激素 (FSH) 和黄体生成素 (LH) 的产生。在结构上，UGRP1 以同二聚体形式存在，通过二硫键连接在一起，也可以作为单体发挥作用。此外，它与 APOA1 相互作用，使其参与多种生理过程又增加了一层。

Human

E. coli

Tag Free

Q96PL1 ( F22-V93)

117156  [NCBI]

FLINKVPLPVDKLAPLPLDNILPFMDPLKLLLKTLGISVEHLVEGLRKCVNELGPEASEAVKKLLEALSHLV

Approximately 6&7 kDa

Greater than 95% as determined by reducing SDS-PAGE

无菌粉末.

Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4.

<1 EU/μg, determined by LAL method.

It is not recommended to reconstitute to a concentration less than 100 μg/mL in ddH₂O. For long term storage it is recommended to add a carrier protein (0.1% BSA, 5% HSA, 10% FBS or 5% Trehalose).

Stored at -20°C for 2 years. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.

Room temperature in continental US;may vary elsewhere.