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  4. ULBP4/RAET1E 蛋白, Human (HEK293, Fc)

ULBP4/RAET1E 蛋白, Human (HEK293, Fc)

目录号: HY-P76690
产品使用指南

ULBP4/RAET1E 蛋白通过结合并激活 KLRK1/NKG2D 受体，至关重要地激活自然杀伤细胞的细胞毒性。这种相互作用介导细胞毒性反应，有助于受体激活并促进标记细胞的识别和靶向消除。ULBP4/RAET1E 与 KLRK1/NKG2D 的结合强调了其在免疫反应调节和自然杀伤细胞活性调节中的重要性。ULBP4/RAET1E 蛋白, Human (HEK293, Fc) 是重组的 ULBP4/RAET1E 蛋白，由 HEK293 表达，带有 C-hFc 标签。

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100 μg   询价  

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描述

ULBP4/RAET1E Protein crucially activates natural killer cell cytotoxicity by binding to and activating the KLRK1/NKG2D receptor. This interaction mediates cytotoxic responses, contributing to receptor activation and facilitating the recognition and targeting of marked cells for elimination. ULBP4/RAET1E's engagement with KLRK1/NKG2D underscores its significance in immune response regulation and natural killer cell activity modulation. ULBP4/RAET1E Protein, Human (HEK293, Fc) is the recombinant human-derived ULBP4/RAET1E protein, expressed by HEK293 , with C-hFc labeled tag.
研究背景

ULBP4/RAET1E 蛋白作为结合并激活 KLRK1/NKG2D 受体的配体，在自然杀伤细胞的细胞毒性中发挥着至关重要的作用。ULBP4/RAET1E 和 KLRK1/NKG2D 之间的相互作用对于介导自然杀伤细胞的细胞毒性反应至关重要。通过与 KLRK1/NKG2D 的结合亲和力，ULBP4/RAET1E 有助于激活该受体，促进识别和靶向标记为消除的细胞。ULBP4/RAET1E 与 KLRK1/NKG2D 的结合强调了其在免疫反应调节和自然杀伤细胞活性调节中的重要性。
种属

Human
表达系统

HEK293
标签

C-hFc
蛋白编号

Q8TD07-1 (H31-D225)
基因 ID
蛋白结构
N-term
ULBP4 (H31-D225)
Accession # Q8TD07-1
hFc
C-term
同用名
Retinoic acid early transcript 1E; NKG2D ligand 4; LETAL; N2DL4
分子量

Approximately 49.1 kDa
纯度

Greater than 90% as determined by reducing SDS-PAGE.
内毒素含量

<1 EU/μg, determined by LAL method.
文件资料
产品使用指南 (1213 KB)

ULBP4/RAET1E Protein, Human (HEK293, Fc) 相关分类

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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The reconstitution calculator equation

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration
= ÷

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2

The specific activity calculator equation

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)
Unit/mg = 106 ÷ ng/mL

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