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  4. ULBP-6/RAET1L 蛋白, Human (HEK293, Fc)

ULBP-6/RAET1L 蛋白, Human (HEK293, Fc)

目录号: HY-P77502
产品使用指南 技术支持

ULBP-6/RAET1L 蛋白是一种关键的免疫反应调节剂，可激活 KLRK1/NKG2D 受体，引发自然杀伤 (NK) 细胞的细胞毒性。这种参与对于免疫系统防御威胁至关重要，展示了 ULBP-6/RAET1L 对 NK 细胞反应的协调。其特异性因在分子相互作用中不存在与 β2-微球蛋白的结合而突出。ULBP-6/RAET1L 蛋白, Human (HEK293, Fc) 是重组的 ULBP-6/RAET1L 蛋白，由 HEK293 表达，带有 C-hFc 标签。

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描述

ULBP-6/RAET1L Protein, a key immune response modulator, activates the KLRK1/NKG2D receptor, triggering natural killer (NK) cell cytotoxicity. This engagement is pivotal for the immune system's defense against threats, showcasing ULBP-6/RAET1L's orchestration of NK cell responses. Its specificity is highlighted by the absence of a binding association with beta2-microglobulin in molecular interactions. ULBP-6/RAET1L Protein, Human (HEK293, Fc) is the recombinant human-derived ULBP-6/RAET1L protein, expressed by HEK293 , with C-hFc labeled tag.
研究背景

NKG2DL2 是免疫反应调节的关键参与者，通过结合并激活 KLRK1/NKG2D 受体发挥其影响。这种相互作用是自然杀伤 (NK) 细胞细胞毒性的关键触发因素，这是免疫系统防御各种威胁的基本方面。NKG2DL2 与 KLRK1/NKG2D 结合的能力强调了其在协调 NK 细胞反应中的作用。值得注意的是，它不与 β2-微球蛋白形成结合关联，进一步阐明了其分子相互作用的特异性。
种属

Human
表达系统

HEK293
标签

C-hFc
蛋白编号

Q5VY80 (R26-S217)
基因 ID

154064  [NCBI]
蛋白结构
N-term
ULBP6 (R26-S217)
Accession # Q5VY80
hFc
C-term
同用名
UL16-binding protein 6; Retinoic acid early transcript 1L protein; ULBP6; RAET1L
分子量

Approximately 48.5 kDa.
纯度

Greater than 90% as determined by reducing SDS-PAGE.
内毒素含量

<1 EU/μg, determined by LAL method.
文件资料
产品使用指南 (1213 KB)

ULBP-6/RAET1L Protein, Human (HEK293, Fc) 相关分类

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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The reconstitution calculator equation

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration
= ÷

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2

The specific activity calculator equation

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)
Unit/mg = 106 ÷ ng/mL

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