ULBP3 蛋白, Human (HEK293, His)

The ULBP3 protein plays a key role in natural killer cell cytotoxicity and activates the KLRK1/NKG2D receptor. The interaction of ULBP3 highlights its importance in mediating cytotoxic responses. ULBP3 Protein, Human (HEK293, His) is the recombinant human-derived ULBP3 protein, expressed by HEK293 , with C-6*His labeled tag. The total length of ULBP3 Protein, Human (HEK293, His) is 187 a.a., with molecular weight of ~59 kDa.

ULBP3 蛋白作为结合并激活 KLRK1/NKG2D 受体的配体，在自然杀伤细胞的细胞毒性中发挥着关键作用。ULBP3 介导自然杀伤细胞的细胞毒性反应。通过与 KLRK1/NKG2D 的结合亲和力，ULBP3 促进该受体的激活，有助于识别和靶向标记为消除的细胞。重要的是，ULBP3 不表现出与 β2-微球蛋白的结合，其相互作用谱的相似性表明了这一点。对 ULBP3 结合特征的深入了解进一步阐明了它作为免疫反应中关键参与者的作用，特别是在自然杀伤细胞活性的协调中。

Measured by its binding ability in a functional ELISA.When Recombinant Human NKG2D/CD314 (HY-P70688) is immobilized at 2 μg/mL (100 μL/well) can bind Recombinant Human ULBP-3. The ED₅₀ for this effect is 1.127 μg/mL.

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  Measured by its binding ability in a functional ELISA.When Recombinant Human NKG2D/CD314 (HY-P70688) is immobilized at 2 μg/mL (100 μL/well) can bind Recombinant Human ULBP-3. The ED₅₀ for this effect is 1.127 μg/mL.

Human

HEK293

C-6*His

Q9BZM4/NP_078794 (D30-P216)

79465

DAHSLWYNFTIIHLPRHGQQWCEVQSQVDQKNFLSYDCGSDKVLSMGHLEEQLYATDAWGKQLEMLREVGQRLRLELADTELEDFTPSGPLTLQVRMSCECEADGYIRGSWQFSFDGRKFLLFDSNNRKWTVVHAGARRMKEKWEKDSGLTTFFKMVSMRDCKSWLRDFLMHRKKRLEPTAPPTMAP

Approximately 25-31 kDa due to the glycosylation.

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  Greater than 95% as determined by reducing SDS-PAGE.

无菌粉末

Lyophilized from a 0.2 μm filtered solution of PBS, pH 6.2, 8% trehalose.

<0.1 EU/μg, determined by LAL method.

It is not recommended to reconstitute to a concentration less than 100 μg/mL in PBS. For long term storage it is recommended to add a carrier protein (0.1% BSA, 5% HSA, 10% FBS or 5% Trehalose).

Stored at -20°C for 2 years. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.

Room temperature in continental US; may vary elsewhere.