uPAR 蛋白, Human (Domain 3, HEK293, His)

uPAR Protein, a receptor for urokinase plasminogen activator, actively localizes and facilitates plasmin formation. It mediates proteolysis-independent signal transduction activated by U-PA and undergoes negative-feedback regulation. As a monomer, it interacts with MRC2, SRPX2, and FAP at invadopodia. Engaging SORL1, it forms a ternary complex with PLAUR, PLAU, and SERPINE1, influencing PLAUR internalization. The interaction with SORL1 occurs via the N-terminal ectodomain, highlighting uPAR's multifaceted role in cellular functions. uPAR Protein, Human (Domain 3, HEK293, His) is the recombinant human-derived uPAR protein, expressed by HEK293, with C-His labeled tag. The total length of uPAR Protein, Human (Domain 3, HEK293, His) is 92 a.a., with molecular weight of 25-35 kDa.

uPAR 蛋白作为尿激酶纤溶酶原激活剂的受体，积极参与纤溶酶形成的定位和促进。此外，它还充当 U-PA 诱导的不依赖于蛋白水解的信号转导激活效应的介质。受到 U-PA 的负反馈调节，uPAR 蛋白会裂解成无活性形式。通常作为单体存在，它与多种蛋白质相互作用，包括 MRC2、SRPX2（通过 UPAR/Ly6 结构域）和 FAP (seprase)，后者相互作用发生在侵袭伪足膜的细胞表面。此外，uPAR 蛋白与 SORL1 相互作用，特别是通过 N 末端胞外域，并且这种相互作用与 PLAUR 内化的减少有关。值得注意的是，由 PLAUR、PLAU（尿激酶型纤溶酶原激活剂）和 SERPINE1 组成的三元复合物的形成也涉及与 SORL1 的相互作用。

Human

HEK293

C-His

Q03405-1 (R214-G305)

5329  [NCBI]

25-35 kDa

Greater than 95% as determined by reducing SDS-PAGE.

<1 EU/μg, determined by LAL method.