1. 重组蛋白
  2. CD Antigens Receptor Proteins
  3. Endothelial cell CD Proteins
  4. U-PAR/CD87
  5. uPAR 蛋白, Human (Domain 3, HEK293, His)

uPAR 蛋白, Human (Domain 3, HEK293, His)

目录号: HY-P700847
产品使用指南

uPAR 蛋白是尿激酶纤溶酶原激活剂的受体,可主动定位并促进纤溶酶形成。它介导由 U-PA 激活的不依赖蛋白水解的信号转导,并经历负反馈调节。作为单体,它在侵袭伪足处与 MRC2、SRPX2 和 FAP 相互作用。它与 SORL1 结合,与 PLAUR、PLAU 和 SERPINE1 形成三元复合物,影响 PLAUR 内化。与 SORL1 的相互作用通过 N 端胞外域发生,突出了 uPAR 在细胞功能中的多方面作用。uPAR 蛋白, Human (Domain 3, HEK293, His) 是重组的 uPAR 蛋白,由 HEK293 表达,带有 C-His 标签。uPAR 蛋白, Human (Domain 3, HEK293, His) 全长 92 个氨基酸,分子量为 25-35 kDa。

MCE 的所有产品仅用作科学研究或药证申报,我们不为任何个人用途提供产品和服务

SPR 检测服务   重组蛋白定制服务

1.  客户无需承担相应的运输费用。

2.  同一机构(单位)同一产品试用装仅限申领一次,同一机构(单位)一年内

     可免费申领三个不同产品的试用装。

3.  试用装只面向终端客户

规格 是否有货
50 μg   询价  
100 μg   询价  

* Please select Quantity before adding items.

  • 生物活性

  • 技术参数

  • 产品性质

  • 产品资料

描述

uPAR Protein, a receptor for urokinase plasminogen activator, actively localizes and facilitates plasmin formation. It mediates proteolysis-independent signal transduction activated by U-PA and undergoes negative-feedback regulation. As a monomer, it interacts with MRC2, SRPX2, and FAP at invadopodia. Engaging SORL1, it forms a ternary complex with PLAUR, PLAU, and SERPINE1, influencing PLAUR internalization. The interaction with SORL1 occurs via the N-terminal ectodomain, highlighting uPAR's multifaceted role in cellular functions. uPAR Protein, Human (Domain 3, HEK293, His) is the recombinant human-derived uPAR protein, expressed by HEK293, with C-His labeled tag. The total length of uPAR Protein, Human (Domain 3, HEK293, His) is 92 a.a., with molecular weight of 25-35 kDa.

研究背景

uPAR 蛋白作为尿激酶纤溶酶原激活剂的受体,积极参与纤溶酶形成的定位和促进。此外,它还充当 U-PA 诱导的不依赖于蛋白水解的信号转导激活效应的介质。受到 U-PA 的负反馈调节,uPAR 蛋白会裂解成无活性形式。通常作为单体存在,它与多种蛋白质相互作用,包括 MRC2、SRPX2(通过 UPAR/Ly6 结构域)和 FAP (seprase),后者相互作用发生在侵袭伪足膜的细胞表面。此外,uPAR 蛋白与 SORL1 相互作用,特别是通过 N 末端胞外域,并且这种相互作用与 PLAUR 内化的减少有关。值得注意的是,由 PLAUR、PLAU(尿激酶型纤溶酶原激活剂)和 SERPINE1 组成的三元复合物的形成也涉及与 SORL1 的相互作用。

种属

Human

表达系统

HEK293

标签

C-His

蛋白编号

Q03405-1 (R214-G305)

基因 ID
蛋白结构
N-term
uPAR (R214-G305)
Accession # Q03405-1
His
C-term
同用名
U-PAR; uPAR; CD87; PLAUR; MO3; UPAR
分子量

25-35 kDa

纯度

Greater than 95% as determined by reducing SDS-PAGE.

内毒素含量

<1 EU/μg, determined by LAL method.

文件资料

uPAR Protein, Human (Domain 3, HEK293, His) 相关分类

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

  • 复溶计算器

  • 重组蛋白稀释计算器

  • 比活力计算器

The reconstitution calculator equation

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration
= ÷

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2

The specific activity calculator equation

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)
Unit/mg = 106 ÷ ng/mL

您最近查看的产品:

Your information is safe with us. * Required Fields.

   产品名称:

 

* 需求量:

* 客户姓名:

 

* Email:

* 电话:

 

* 公司或机构名称:

   留言给我们:

Bulk Inquiry

Inquiry Information

产品名称:
uPAR Protein, Human (Domain 3, HEK293, His)
目录号:
HY-P700847
需求量: