uPAR 蛋白, Mouse (Biotinylated, HEK293, His-Avi)

The uPAR protein acts as a receptor for urokinase plasminogen activator, facilitating plasmin formation and signal transduction activation. It interacts with SRPX2 and forms a monomer. uPAR also interacts with MRC2 and SORL1, reducing PLAUR internalization. Additionally, the PLAUR-PLAU-SERPINE1 complex interacts with SORL1. uPAR Protein, Mouse (Biotinylated, HEK293, His-Avi) is the recombinant mouse-derived uPAR protein, expressed by HEK293 , with C-Avi, C-His labeled tag. The total length of uPAR Protein, Mouse (Biotinylated, HEK293, His-Avi) is 275 a.a., with molecular weight of 50-70 kDa.

uPAR 蛋白作为尿激酶纤溶酶原激活剂的受体发挥作用，在纤溶酶的定位和促进形成中起着至关重要的作用。此外，它介导 U-PA 的信号转导激活作用，与蛋白水解无关。它主要作为单体存在，并通过其 UPAR/Ly6 结构域与 SRPX2 相互作用。uPAR 还与 MRC2 和 SORL1 相互作用，后者相互作用减少 PLAUR 内化。此外，由PLAUR-PLAU-SERPINE1组成的三元复合物也与SORL1相互作用。

Human PLAU, His Tag immobilized on CM5 Chip can bind Biotinylated Mouse uPAR, His Tag with an affinity constant of 418.50 nM as determined in SPR assay (Biacore T200).

Mouse

HEK293

C-Avi;C-His

P35456-1 (L24-G298)

/

50-70 kDa

Greater than 95% as determined by reducing SDS-PAGE.

无菌粉末

Lyophilized from a 0.22 μm filtered solution of PBS, pH 7.4. Normally 8% trehalose is added as protectant before lyophilization.

<1 EU/μg, determined by LAL method.

It is not recommended to reconstitute to a concentration less than 100 μg/mL in ddH₂O.

Stored at -20°C for 2 years. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.

Room temperature in continental US; may vary elsewhere.