VEGF-CC 蛋白, Human (116a.a, HEK293, His)

The VEGF-CC protein is a potent growth factor in angiogenesis and endothelial cell growth, stimulating cell proliferation and migration while affecting vascular permeability. It plays a critical role in embryonic vein and lymphangiogenesis and maintains adult differentiated lymphatic endothelium. VEGF-C Protein, Human (116a.a, HEK293, His) is the recombinant human-derived VEGF-C protein, expressed by HEK293 , with C-6*His labeled tag. The total length of VEGF-C Protein, Human (116a.a, HEK293, His) is 116 a.a., with molecular weight of ~19.42 kDa.

VEGF-CC蛋白是一种生长因子，对血管生成和内皮细胞生长具有显着活性，有效刺激其增殖和迁移，同时影响血管的通透性。这种多面蛋白参与胚胎发生过程中静脉和淋巴管系统内的血管生成，并有助于维持成人分化的淋巴管内皮。VEGF-CC 通过结合并激活受体 KDR/VEGFR2 和 FLT4/VEGFR3 来实现这些功能。在结构上，VEGF-CC 以同二聚体形式存在，表现出非共价和反向平行排列。该蛋白与 FLT4/VEGFR3 的相互作用至关重要，因为它是 FLT4/VEGFR3 同二聚化和随后激活所必需的。这些特征共同强调了 VEGF-CC 在调节血管过程中的不同作用，并强调了其在发育和成人血管生成中的重要性。

Measured in a cell proliferation assay using HUVEC human umbilical vein endothelial cells. The ED₅₀ for this effect is 5.559 ng /mL, corresponding to a specific activity is 1.80×10⁵ U/mg.

Human

HEK293

C-6*His

P49767 (A112-R227)

7424  [NCBI]

AHYNTEILKSIDNEWRKTQCMPREVCIDVGKEFGVATNTFFKPPCVSVYRCGGCCNSEGLQCMNTSTSYLSKTLFEITVPLSQGPKPVTISFANHTSCRCMSKLDVYRQVHSIIRR

Approximately 19.42 kDa

• 
  Greater than 95% as determined by reducing SDS-PAGE.

无菌粉末.

Lyophilized from a 0.2 μm filtered solution of 20 mM PB, 150 mM NaCl, pH 7.4.

<1 EU/μg, determined by LAL method.

It is not recommended to reconstitute to a concentration less than 100 μg/mL in ddH₂O. For long term storage it is recommended to add a carrier protein (0.1% BSA, 5% HSA, 10% FBS or 5% Trehalose).

Stored at -20°C for 2 years. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.

Room temperature in continental US; may vary elsewhere.