VEGFR-1 蛋白, Human (730a.a, HEK293, Fc)

The VEGFR-1 protein is a tyrosine protein kinase that acts as a cell surface receptor for VEGFA, VEGFB, and PGF. It plays a crucial role in embryonic vasculature development, regulation of angiogenesis, cell survival, migration, macrophage function, chemotaxis, and cancer cell invasion. VEGFR-1 Protein, Human (730a.a, HEK293, Fc) is the recombinant human-derived VEGFR-1 protein, expressed by HEK293 , with C-hFc labeled tag.

VEGFR-1 蛋白是一种酪氨酸蛋白激酶，作为 VEGFA、VEGFB 和 PGF 的细胞表面受体。它在各种生物过程中发挥着至关重要的作用，包括胚胎脉管系统发育、血管生成调节、细胞存活、细胞迁移、巨噬细胞功能、趋化性和癌细胞侵袭。此外，VEGFR-1 作为出生后视网膜玻璃体血管退化的正调节因子，并可能通过抑制过度的内皮细胞增殖作为胚胎血管生成的负调节因子。在成年期，它促进内皮细胞增殖、存活和血管生成，尽管其增殖作用似乎具有细胞类型特异性。VEGFR-1 对 VEGFA 具有高亲和力，通过限制游离 VEGFA 的可用性并阻止其与 KDR 结合，充当其信号转导的负调节因子。它通过与 KDR 形成异二聚体来调节 KDR 信号传导。配体与 VEGFR-1 结合可激活多种信号级联反应，包括 PLCG、MAPK1/ERK2、MAPK3/ERK1、AKT1 和 PI3K 通路。VEGFR-1 还磷酸化 SRC、YES1、CBL、AKT1、PTK2/FAK1 和 PLCG。

Human

HEK293

C-hFc

P17948-1 (S27-N756)

2321  [NCBI]

SKLKDPELSLKGTQHIMQAGQTLHLQCRGEAAHKWSLPEMVSKESERLSITKSACGRNGKQFCSTLTLNTAQANHTGFYSCKYLAVPTSKKKETESAIYIFISDTGRPFVEMYSEIPEIIHMTEGRELVIPCRVTSPNITVTLKKFPLDTLIPDGKRIIWDSRKGFIISNATYKEIGLLTCEATVNGHLYKTNYLTHRQTNTIIDVQISTPRPVKLLRGHTLVLNCTATTPLNTRVQMTWSYPDEKNKRASVRRRIDQSNSHANIFYSVLTIDKMQNKDKGLYTCRVRSGPSFKSVNTSVHIYDKAFITVKHRKQQVLETVAGKRSYRLSMKVKAFPSPEVVWLKDGLPATEKSARYLTRGYSLIIKDVTEEDAGNYTILLSIKQSNVFKNLTATLIVNVKPQIYEKAVSSFPDPALYPLGSRQILTCTAYGIPQPTIKWFWHPCNHNHSEARCDFCSNNEESFILDADSNMGNRIESITQRMAIIEGKNKMASTLVVADSRISGIYICIASNKVGTVGRNISFYITDVPNGFHVNLEKMPTEGEDLKLSCTVNKFLYRDVTWILLRTVNNRTMHYSISKQKMAITKEHSITLNLTIMNVSLQDSGTYACRARNVYTGEEILQKKEITIRDQEAPYLLRNLSDHTVAISSSTTLDCHANGVPEPQITWFKNNHKIQQEPGIILGPGSSTLFIERVTEEDEGVYHCKATNQKGSVESSAYLTVQGTSDKSN

150-175 kDa

Greater than 95% as determined by reducing SDS-PAGE.

<1 EU/μg, determined by LAL method.