West Nile Virus NS1 蛋白 (HEK293, His)

West Nile Virus NS1 Protein is a glycoprotein among the flavivirus genus. It is found in both membrane-associated and soluble secreted forms. WNV NS1 has an unusual structure-function because it is glycosylated and forms different structures to facilitate different roles intracellularly and extracellularly, including roles in the replication complex, assisting in virus assembly, and complement antagonism. It also plays a role in protective immunity through antibody-mediated cellular cytotoxicity, and anti-NS1 antibodies elicit passive protection in animal models against a virus challenge. West Nile Virus NS1 Protein (HEK293, His) is the recombinant Virus-derived West Nile Virus NS1 protein, expressed by HEK293 , with N-His labeled tag.

西尼罗河病毒 NS1 (WNV NS1) 是黄病毒属的一种糖蛋白。它以膜相关形式和可溶性分泌形式存在。WNV NS1 具有不寻常的结构功能，因为它被糖基化并形成不同的结构，以促进细胞内和细胞外的不同作用，包括在复制复合体中的作用、协助病毒组装和补体拮抗作用。它还通过抗体介导的细胞毒性在保护性免疫中发挥作用，抗 NS1 抗体在动物模型中引发针对病毒攻击的被动保护。WNV NS1 可能通过影响 Toll 样受体 3 (TLR3) 信号通路，抑制 IRF3 和 NF-κB 核转位，从而抑制 IFN-β 启动子和核因子 κB (NF-κB) 启动子的激活。此外，它还通过直接与 RIG-I 和 MDA5 相互作用并导致它们降解来靶向它们，从而抑制 IRF3 的激活和 IFN-β 的表达。NS1 由于其补体固定特性和特异性而被用作黄病毒感染的诊断标记物^[1][2]。

Virus

HEK293

N-His

YP_001527881.1 (D1-A352)

5714902  [NCBI]

Approximately 42.1 kDa

Greater than 95% as determined by reducing SDS-PAGE.

<1 EU/μg, determined by LAL method.