2. Cell Cycle/DNA Damage Apoptosis
  3. DNA/RNA Synthesis Apoptosis
  4. (rel)-Oxaliplatin

(rel)-Oxaliplatin 是一种 DNA 合成抑制剂。(rel)-Oxaliplatin 引起 DNA 交联损伤，阻止 DNA 复制和转录，并诱导细胞凋亡。(rel)-Oxaliplatin 可用于癌症研究。

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(rel)-Oxaliplatin Chemical Structure

(rel)-Oxaliplatin Chemical Structure

CAS No. : 63121-00-6

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(rel)-Oxaliplatin 相关抗体

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  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

(rel)-Oxaliplatin is a DNA synthesis inhibitor. (rel)-Oxaliplatin causes DNA crosslinking damage, prevents DNA replication and transcription and induces apoptosis. (rel)-Oxaliplatin can be used for cancer research[1][2][3].

体外研究
(In Vitro)

(rel)-Oxaliplatin (24-72 hours; 2-128 μM; HCC, HCCLM3 and Hep3B cells) inhibits cell growth and induces apoptosis[1].
(rel)-Oxaliplatin (10 μM; 15-240 mins; CEM cells ) induces primary and secondary DNA lesions, including DNA cross-links (ISC) and DNA-protein cross-links (DPC)[2].
(rel)-Oxaliplatin (0.01 to 100 μM; 24 hours) potently inhibits bladder carcinoma cell lines RT4 and TCCSUP, ovarian carcinoma cell line A2780, colon carcinoma cell line HT-29, glioblastoma cell lines U-373MG and U-87MG, and melanoma cell lines SK-MEL-2 and HT-144 with IC50 of 11 μM, 15 μM, 0.17 μM, 0.97 μM, 2.95 μM, 17.6 μM, 30.9 μM and 7.85 μM, respectively[3]

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

(rel)-Oxaliplatin 相关抗体:

Cell Viability Assay[1]

Cell Line: HCC, HCCLM3 and Hep3B cells
Concentration: 24, 48 and 72 hours
Incubation Time: 2, 4, 8, 16, 32, 64 and 128 μM
Result: Decreased cell viability in a dose- and time-dependent manner.

Western Blot Analysis[1]

Cell Line: HCCLM3 and Hep3B cells
Concentration: 48 hours
Incubation Time: 10 μM
Result: Down-regulated the expression of Bcl-2 and Bcl-xL, and increased the expression of Bax.

Cell Cycle Analysis[1]

Cell Line: HCCLM3 and Hep3B cells
Concentration: 24 hours
Incubation Time: 10 μM
Result: Increased the percentage of apoptotic cells (17.70% for HCCLM3 cells; 21.19% for Hep3B cells).
体内研究
(In Vivo)

(rel)-Oxaliplatin (5-10 mg/kg; i.p.; for 32 days; nude mice) inhibits tumor growth[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Nude mice[1]
Dosage: 5 and 10 mg/kg
Administration: Intraperitoneal injection; for 32 days
Result: Reduced tumor volume in HCCLM3 tumor xenografts.
分子量

397.29

Formula

C8H14N2O4Pt
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

(rel)-Oxaliplatin 相关分类

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  • 稀释计算器

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

(rel)-Oxaliplatin63121-00-6DNA/RNA SynthesisApoptosisapoptosisDNA cross-linksDNA-protein cross-linksanticancerInhibitorinhibitorinhibit

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