Resiquimod (Synonyms: R848; S28463)

目录号: HY-13740G: FAQs
Data Sheet 产品使用指南

摩尔计算器

Resiquimod (R848) (GMP) 是 GMP 级别的 Resiquimod (HY-13740)。GMP 级别的小分子可用做细胞疗法中的辅助试剂。Resiquimod 是一种 Toll 样受体 7 和 8 (TLR7/TLR8) 激动剂。Resiquimod (GMP) 可诱导人 mMDSC 分化成熟为炎性巨噬细胞。

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Resiquimod Chemical Structure

CAS No. : 144875-48-9

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10 mg	￥11880	In-stock
50 mg	￥37800	In-stock
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TLR3 TLR8 TLR9 TLR2 TLR4 TLR7 TLR1 TLR6

生物活性
纯度 & 产品资料
参考文献

生物活性

Resiquimod (R848) (GMP) is Resiquimod (HY-13740) produced by using GMP guidelines. GMP small molecules work appropriately as an auxiliary reagent for cell therapy manufacture. Resiquimod is a Toll-like receptor 7 and 8 (TLR7/TLR8) agonist. Resiquimod (GMP) can induce human mMDSC to mature into inflammatory macrophages^[1]^[2]^[3].

IC₅₀ & Target^[1]

TLR7

TLR8

细胞效力
(Cellular Effect)

Cell Line	Type	Value	Description	References
HEK293	EC₅₀	0.75 μM Compound: R848	Agonist activity at human TLR7 expressed in HEK293 cells assessed as induction of NFKappaB activity after 24 hrs by SEAP reporter gene assay Agonist activity at human TLR7 expressed in HEK293 cells assessed as induction of NFKappaB activity after 24 hrs by SEAP reporter gene assay	[PMID: 32001135]
HEK293	EC₅₀	1.4 μM Compound: 2	Agonist activity at human TLR7 transfected in HEK cells assessed as NFkappaB induction after 24 hrs by specific secreted alkaline phosphatase gene assay Agonist activity at human TLR7 transfected in HEK cells assessed as NFkappaB induction after 24 hrs by specific secreted alkaline phosphatase gene assay	[PMID: 22837811]
HEK293	EC₅₀	1.5 μM Compound: 2	Agonist activity at human TLR-7 expressed in HEK293 cells after 24 hrs by SEAP reporter gene assay Agonist activity at human TLR-7 expressed in HEK293 cells after 24 hrs by SEAP reporter gene assay	[PMID: 24383475]
HEK293	EC₅₀	260.1 nM Compound: 2	Agonist activity at human TLR7 expressed in HEK293 cells coexpressing pNiFty2-SEAP reporter by reporter gene assay Agonist activity at human TLR7 expressed in HEK293 cells coexpressing pNiFty2-SEAP reporter by reporter gene assay	[PMID: 20232824]
HEK293	EC₅₀	4 μM Compound: Resiquimod	Agonist activity at human TLR8 expressed in HEK293 cells incubated for 6 hrs by luciferase reporter gene assay Agonist activity at human TLR8 expressed in HEK293 cells incubated for 6 hrs by luciferase reporter gene assay	[PMID: 27270029]
HEK293	EC₅₀	4.5 μM Compound: 2	Agonist activity at human TLR-8 expressed in HEK293 cells after 24 hrs by SEAP reporter gene assay Agonist activity at human TLR-8 expressed in HEK293 cells after 24 hrs by SEAP reporter gene assay	[PMID: 24383475]
HEK293	EC₅₀	5.87 μM Compound: R848	Agonist activity at human TLR8 expressed in HEK293 cells assessed as induction of NFKappaB activity after 24 hrs by SEAP reporter gene assay Agonist activity at human TLR8 expressed in HEK293 cells assessed as induction of NFKappaB activity after 24 hrs by SEAP reporter gene assay	[PMID: 32001135]
HEK293	EC₅₀	6.4 μM Compound: 2	Agonist activity at human TLR8 transfected in HEK cells assessed as NFkappaB induction after 24 hrs by specific secreted alkaline phosphatase gene assay Agonist activity at human TLR8 transfected in HEK cells assessed as NFkappaB induction after 24 hrs by specific secreted alkaline phosphatase gene assay	[PMID: 22837811]
PBMC	EC₅₀	24 nM Compound: R848	Antiviral activity against HCV infected human Huh7 replicon cells treated for 48 hrs with drug-induced mixed donor human PBMC supernatants assessed as viral levels by luciferase assay Antiviral activity against HCV infected human Huh7 replicon cells treated for 48 hrs with drug-induced mixed donor human PBMC supernatants assessed as viral levels by luciferase assay	[PMID: 17548497]
PBMC	EC₅₀	26.5 nM Compound: R848	Antiviral activity against HCV infected human Huh7 replicon cells treated for 48 hrs with drug-induced single donor human PBMC supernatants assessed as viral levels by luciferase assay Antiviral activity against HCV infected human Huh7 replicon cells treated for 48 hrs with drug-induced single donor human PBMC supernatants assessed as viral levels by luciferase assay	[PMID: 17548497]

体外研究
(In Vitro)

Resiquimod (GMP) (3 µg/mL，5 天) 诱导人 mMDSC 成熟为炎性巨噬细胞 (MAC_inflam)^[1]。
Resiquimod (GMP) (3 µg/mL，3 天) 在人 mMDSC 中产生 IL-6 和 IL-12^[1]。
Resiquimod (GMP) (2.5 µg/mL，7 天) 将记忆 B 细胞转分化为产生 IgG 的浆细胞^[2]。
Resiquimod (GMP) (5 µg/mL，5 天) 诱导 MDSCs 分化为成熟的骨髓细胞^[3]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Clinical Trial

分子量

314.38

Formula

C₁₇H₂₂N₄O₂

CAS 号

144875-48-9

性状

固体

颜色

White to off-white

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

纯度 & 产品资料

产品使用指南 (1538 KB)

参考文献

[1]. Bayik D, et al. Factors Influencing the Differentiation of Human Monocytic Myeloid-Derived Suppressor Cells Into Inflammatory Macrophages. Front Immunol. 2018 Mar 26;9:608. [Content Brief]

[2]. Preisendörfer S, et al. FK506-Binding Protein 11 Is a Novel Plasma Cell-Specific Antibody Folding Catalyst with Increased Expression in Idiopathic Pulmonary Fibrosis. Cells. 2022 Apr 14;11(8):1341. [Content Brief]

[3]. Lee M, et al. Resiquimod, a TLR7/8 agonist, promotes differentiation of myeloid-derived suppressor cells into macrophages and dendritic cells. Arch Pharm Res. 2014;37(9):1234-40. [Content Brief]

Resiquimod 相关分类

摩尔计算器
稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量		浓度		体积		分子量 *
	=		×		×

The dilution calculator equation

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

浓度 _(start)	×	体积 _(start)	=	浓度 _(final)	×	体积 _(final)
	×		=		×
C1		V1		C2		V2

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Resiquimod (GMP)144875-48-9R848 (GMP) S28463 (GMP)Toll-like Receptor (TLR)GMPcell therapydifferentiationMDSCmacrophagemyeloid cellInhibitorinhibitorinhibit

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MedChemExpress (MCE) 只为有资质的科研机构、医药企业基于科学研究或药证申报的用途提供医药研发服务，不为任何个人或者非科研性质的、非用于药证申报使用等其他用途提供服务。

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营业执照（三证合一）

Resiquimod (Synonyms: R848; S28463)

Customer Review

Other Forms of Resiquimod:

Resiquimod 相关产品

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•同靶点蛋白产品:

查看 Toll-like Receptor (TLR) 亚型特异性产品:

生物活性

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Resiquimod 相关分类

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Resiquimod (Synonyms: R848; S28463)

Customer Review

Other Forms of Resiquimod:

Resiquimod 相关抗体

Resiquimod 相关产品

•同靶点产品:

•同靶点蛋白产品:

查看 Toll-like Receptor (TLR) 亚型特异性产品:

生物活性

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参考文献

Resiquimod 相关抗体:

Resiquimod 相关分类

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The molarity calculator equation

The dilution calculator equation

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