2. GPCR/G Protein Apoptosis Cell Cycle/DNA Damage
  3. Neuropeptide FF Receptor Apoptosis MDM-2/p53 PERK
  4. RFRP-3 (mouse)

RFRP-3 (mouse)  (Synonyms: Neuropeptide NPVF (mouse))

目录号: HY-P10780
产品使用指南 技术支持

RFRP-3 (mouse) 是禽类促性腺激素抑制激素 (GnIH) 的功能同源物，与 GPR147 结合。RFRP-3 (mouse) 通过抑制 FSHR 和 参与类固醇生成的关键酶 (P450scc、3β-HSD、StAR) 来减少Progesterone 的合成。RFRP-3 (mouse) 诱导细胞凋亡 (Apoptosis) (p53 增加)。RFRP-3 (mouse) 还能抑制 ERK 信号通路。RFRP-3 可用于卵泡发育研究。

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Custom Peptide Synthesis

RFRP-3 (mouse) Chemical Structure

RFRP-3 (mouse) Chemical Structure

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RFRP-3 (mouse) 相关抗体

Top Publications Citing Use of Products

查看 Neuropeptide FF Receptor 亚型特异性产品:

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NPFFR1 NPFFR2

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

RFRP-3 (mouse) is a functional ortholog of avian gonadotropin inhibitory hormone (GnIH), binding to GPR147. RFRP-3 (mouse) reduces Progesterone synthesis by inhibiting FSHR and key enzymes involved in steroidogenesis (P450scc, 3β-HSD, StAR). RFRP-3 (mouse) induces Apoptosis (increase of p53). RFRP-3 (mouse) also suppresses the ERK signaling pathway. RFRP-3 (mouse) can be used for research of follicular development[1].

体外研究
(In Vitro)

RFRP-3 (10-1000 ng/mL, 24 h) 能显著减少小鼠卵巢颗粒细胞中 Progesterone (HY-N0437) 的分泌，但不能减少 Estradiol (HY-B0141) 的分泌[1]。
RFRP-3 (10-1000 ng/mL, 24 h) 抑制小鼠卵巢颗粒细胞中类固醇生成和 FSHR (抑制 p450scc、3β-HSD、StAR 和 FSHR)[1]。
RFRP-3 (10-1000 ng/mL, 24 h) 诱导小鼠卵巢颗粒细胞凋亡，在中等剂量下降低 Bcl-2 蛋白表达，增加 p53 蛋白表达[1]。
RFRP-3 (10-1000 ng/mL, 24 h) 抑制小鼠卵巢颗粒细胞中 ERK 信号通路 (p-ERK1/2 蛋白)[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

RFRP-3 (mouse) 相关抗体:

Real Time qPCR[1]

Cell Line: Granulosa cells
Concentration: 10, 100, 1000 ng/mL
Incubation Time: 24 h
Result: Reduced p450scc mRNA expression at 100 ng/mL, but did not significantly alter p450scc expression at low dose (10 ng/mL) and high dose (1000 ng/mL).
Reduced 3β-HSD, FSHR and StAR expression at 100 ng/mL and 1000 ng/mL, whereas had no significant effect at 10 ng/mL.
分子量

2073.34

Formula

C91H141N29O25S
Sequence

Val-Asn-Met-Glu-Ala-Gly-Thr-Arg-Ser-His-Phe-Pro-Ser-Leu-Pro-Gln-Arg-Phe-NH2
Sequence Shortening

VNMEAGTRSHFPSLPQRF-NH2
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

RFRP-3 (mouse) 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

RFRP-3 (mouse)Neuropeptide NPVF (mouse)Neuropeptide FF ReceptorApoptosisMDM-2/p53PERKProtein kinase R-like endoplasmic reticulum kinasePKR-like endoplasmic reticulum kinaseGranulosa cellsFollicleICRGnIHProgesteroneOvarian.Inhibitorinhibitorinhibit

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