2. Membrane Transporter/Ion Channel Neuronal Signaling
  3. nAChR
  4. RGH-560

RGH-560 (compound 53) 显示出高度的 α7 nAChR 正调节剂活性和有利的理化特征。RGH-560 有强大的体内促认知潜力。RGH-560 能够用于 Scopolamine (HY-N0296) 引起的小鼠认知障碍的研究。

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RGH-560 Chemical Structure

RGH-560 Chemical Structure

CAS No. : 2408799-43-7

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RGH-560 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

RGH-560 (compound 53) shows highly advanced α7 nAChR positive modulator properties and favorable physicochemical features. RGH-560 has robust procognitive in vivo potential. RGH-560 can be used to study Scopolamine (HY-N0296) -induced amnesia in mice[1].

体内研究
(In Vivo)

RGH-560 (compound 53) (1 mg/kg, 3 mg/kg, 10 mg/kg;腹腔注射) 对东莨菪碱 (HY-N0296) 引起的小鼠遗忘症具有显著的认知增强作用。RGH-560 是一种中等清除率化合物。RGH-560剂量高达 30 mg/kg 时，对小鼠无毒性[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Mice with scopolamine-induced amnesia[1]
Dosage: 1 mg/kg, 3 mg/kg, 10 mg/kg
Administration: Intraperitoneal injection (i.p.)
Result: Reversed the scopolamine-induced cognitive impairment.
分子量

393.41

Formula

C22H20FN3O3
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

RGH-560 相关分类

  • 摩尔计算器

  • 稀释计算器

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

RGH-5602408799-43-7RGH560RGH 560nAChRNicotinic acetylcholine receptorsScopolamine-induced AmnesiaAgonistInhibitorinhibitorinhibit

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