2. Protein Tyrosine Kinase/RTK
  3. VEGFR
  4. Rhamnazin

Rhamnazin 是一种具有口服活性的 VEGFR2 信号通路抑制剂，对 VEGFR2 激酶的 IC50 为 4.68 μM。Rhamnazin 具有较强的抗血管生成活性和抗肿瘤作用。Rhamnazin 具有抗氧化和抗炎作用。

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Rhamnazin Chemical Structure

Rhamnazin Chemical Structure

CAS No. : 552-54-5

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规格 价格 是否有货 数量
1 mg ￥3043
3 - 4 周
5 mg 现货 3 - 4 周
10 mg   询价  
50 mg   询价  

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Rhamnazin 相关抗体

Top Publications Citing Use of Products

查看 VEGFR 亚型特异性产品:

查看所有亚型
VEGFR1/Flt-1 VEGFR2/KDR/Flk-1 VEGFR3/Flt-4

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Rhamnazin is an orally active inhibitor of VEGFR2 signaling with an IC50 of 4.68 μM against VEGFR2 kinase. Rhamnazin shows potent antiangiogenic activity and antitumor efficacy[1]. Rhamnazin shows antioxidant and anti-inflammatory properties[2].

IC50 & Target[1]

VEGFR2

4.68 μM (IC50)

体外研究
(In Vitro)

Rhamnazin (5-40 μM) 抑制 VEGF 诱导的 HUVECs 增殖、迁移和成管[1]。
Rhamnazin (0-20 μM) 降低 VEGFR-2 酪氨酸激酶活性和 VEGFR-2 信号通路[1]。
Rhamnazin (0-40 μM; 24 h) 抑制乳腺癌细胞增殖和 VEGFR2 信号通路[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Rhamnazin 相关抗体:

Cell Migration Assay [1]

Cell Line: HUVECs
Concentration: 0, 10, 15 and 20 μM
Incubation Time: 6 h
Result: Strongly inhibited the migration of HUVECs.

Western Blot Analysis[1]

Cell Line: HUVECs
Concentration: 0, 10, 15 and 20 μM
Incubation Time: 24 h
Result: Decreased VEGF binding to VEGFR2. Reduced VEGF-stimulated phosphorylation of VEGFR2 and its downstream MAPK, AKT, and STAT3 in HUVECs in a concentrationdependent manner.

Cell Proliferation Assay[1]

Cell Line: HCC1937, T-47D, SK-BR-3, MCF-7 and MDA-MB-231
Concentration: 0, 10, 15, 20, 30 and 40 μM
Incubation Time: 24 h
Result: Inhibited cell growth with IC50s of 19, 27, 32, 41 and 64 μM against MDA-MB-231, MCF-7, SK-BR-3, T-47D and HCC1937 in the presence of VEGF, respectively.
体内研究
(In Vivo)

Rhamnazin (200 mg/kg; i.g.; daily for 25 days) 抑制小鼠乳腺癌生长和血管生成[1]。
Rhamnazin (5-20 mg/kg; i.p.; once) 在大鼠急性肺损伤模型中显示出较强的抗氧化和抗炎作用[2]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: BALB/c nude mice, breast cancer xenograft model[1]
Dosage: 200 mg/kg
Administration: Intragastric administration, daily for 25 days
Result: Dramatically suppressed tumor volumes by 47% compared with the vehicle group. Showed a significant reduction of pVEGFR2Tyr951-positive cells in tumors. Resulted in downregulation of VEGFR2 downstream molecules phosphorylation including MAPK, AKT and STAT3.
分子量

330.29

Formula

C17H14O7
CAS 号
结构分类
初始来源
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Rhamnazin 相关分类

  • 摩尔计算器

  • 稀释计算器

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Rhamnazin552-54-5VEGFRVascular endothelial growth factor receptorHCC1937T-47DSK-BR-3MCF-7MDA-MB-231HUVECsInhibitorinhibitorinhibit

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