2. Protein Tyrosine Kinase/RTK
  3. c-Met/HGFR
  4. Rilotumumab

Rilotumumab  (Synonyms: 利妥木单抗; AMG 102)

目录号: HY-P99217 纯度: 99.10%
COA

摩尔计算器

Rilotumumab (AMG 102) 是一种 anti-HGF (抗肝细胞生长因子) 的单克隆抗体，抑制 HGF/MET 驱动的信号传导。Rilotumumab 具有抗肿瘤活性，可用于去势抵抗性前列腺癌 (CRPC) 和实体瘤的研究。

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CAS No. : 872514-65-3

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5 mg ￥7200
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Rilotumumab 相关抗体

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  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Rilotumumab (AMG 102) is an anti-HGF (anti-hepatocyte growth factor) monoclonal antibody, inhibits HGF/MET-driven signaling. Rilotumumab shows anti-tumor activity, and can be used in castration-resistant prostate cancer (CRPC) and solid tumor research[1][2].

同型

Human IgG2 kappa
推荐同型对照抗体
种属

Human
体外研究
(In Vitro)

Rilotumumab (10 μg/mL; overnight) shows the decrease of MET phosphorylation at Y1234 and Y1235, and an increase in total MET[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Rilotumumab 相关抗体:

Western Blot Analysis[2]

Cell Line: U87MG.vIII cells
Concentration: 10 μg/mL
Incubation Time: Overnight
Result: Showed MET phosphorylation at tyrosine residue 1234 (Y1234) and Y1235 ~50% lower in U87MG.vIII cells than in untreated cells.
Showed an increase in total MET compared with untreated cells.
体内研究
(In Vivo)

Rilotumumab (intraperitoneal injection; 1.5 mg/kg; once two days; 11 d) treatment inhibits glioma cell growth in vivo[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: 6-8-week-old BALB/c nu/nu female mice subcutaneous injected with U87MG.vIII cells[2]
Dosage: 1.5 mg/kg
Administration: Intraperitoneal injection; 1.5 mg/kg; once two days; 11 days
Result: Reduced U87MG.vIII xenograft growth (P=0.0002) compared with vehicle-treated xenografts (P=0.0001).
Clinical Trial
CAS 号
性状

液体

颜色

Colorless to light yellow

中文名称

利妥木单抗
运输条件

Shipping with dry ice.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
Format
  • Human IgG2 kappa
纯度 & 产品资料
参考文献

Rilotumumab 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Rilotumumab872514-65-3AMG 102利妥木单抗AMG102AMG-102c-Met/HGFRhepatocyte growth factorcastration-resistant prostate cancerCRPCsolid tumorU87MG.vIII cellInhibitorinhibitorinhibit

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