2. Immunology/Inflammation Vitamin D Related/Nuclear Receptor
  3. Glucocorticoid Receptor
  4. Rimexolone

Rimexolone  (Synonyms: Org 6216; Rimexel)

目录号: HY-B1754
产品使用指南 技术支持

Rimexolone (Org 6216) 是一种具有抗炎活性的糖皮质激素。Rimexolone 可作为 1% 的眼悬液用于眼部炎症的研究。

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Rimexolone Chemical Structure

Rimexolone Chemical Structure

CAS No. : 49697-38-3

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规格 价格 是否有货 数量
100 mg ￥9331
3 - 4 周
200 mg   询价  
500 mg   询价  

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Customer Review

Rimexolone 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Rimexolone (Org 6216) is a glucocorticoid steroid with anti-inflammatory activity. Rimexolone can be used as a 1% ophthalmic suspension for the management of ocular inflammation[1][2].

细胞效力
(Cellular Effect)
Cell Line Type Value Description References
HepG2 EC50
0.68 μM
Compound: Rimexolone
Activation of rat PXR expressed in human HepG2 cells after 24 hrs by luciferase reporter gene based luminescent analysis
Activation of rat PXR expressed in human HepG2 cells after 24 hrs by luciferase reporter gene based luminescent analysis
[PMID: 20966043]
HepG2 EC50
1.6 μM
Compound: Rimexolone
Activation of human PXR expressed in human HepG2 (DPX-2) cells assessed as induction of CYP3A4 after 24 hrs by luminescent analysis
Activation of human PXR expressed in human HepG2 (DPX-2) cells assessed as induction of CYP3A4 after 24 hrs by luminescent analysis
[PMID: 20966043]
HepG2 EC50
4 μM
Compound: Rimexolone
Activation of human PXR expressed in human HepG2 (DPX-2) cells after 24 hrs by luciferase reporter gene based luminescent analysis
Activation of human PXR expressed in human HepG2 (DPX-2) cells after 24 hrs by luciferase reporter gene based luminescent analysis
[PMID: 20966043]
体外研究
(In Vitro)

Rimexolone (Org 6216) shows highly enhanced persistence at the injection site, minimal systematic effects and virtually does not induce skin artrophy[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Rimexolone 相关抗体:
体内研究
(In Vivo)

Rimexolone (Org 6216) (0-450 μg/mouse; intraarticular injection; once) shows prolonged anti-inflammatory action in mice with monoarticular antigen-induced arthritis[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Male, 8-12 weeks old C57Black/6 mice with antigen induced arthritis[1]
Dosage: 5, 25, 50, 150, 250, 450 μg/mouse
Administration: Intraarticular injection, once
Result: Suppressed the arthritis in a dose-dependent manner.
Significantly prevented osteophyte formation at 450 and 150 μg.
Resulted in a decrease of the inhibition of the chondrocyte proteoglycan synthesis.
Clinical Trial
分子量

370.52

Formula

C24H34O3
CAS 号
中文名称

利美索龙
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Rimexolone 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Rimexolone49697-38-3Org 6216 Rimexel利美索龙Org6216Org-6216Glucocorticoid Receptoranti-inflammatory activityocular inflammationminimal systematic effectsarthritisInhibitorinhibitorinhibit

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