2. MAPK/ERK Pathway Apoptosis
  3. Mixed Lineage Kinase RIP kinase
  4. RIPK3-IN-3

RIPK3-IN-3 (compound 20) 是 RIP 激酶 (RIP kinase) RIPK3 的选择性抑制剂 (IC50=10 nM)。RIPK3 介导 Mixed Lineage Kinase (MLKL) 磷酸化并引起坏死性凋亡，RIPK3-IN-3 则抑制 p-MLKL 寡聚化从而抑制坏死性凋亡。RIPK3-IN-3 还下调 CXCL5 分泌，抑制 AsPC-1 细胞迁移和侵袭。

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RIPK3-IN-3 Chemical Structure

RIPK3-IN-3 Chemical Structure

CAS No. : 3052303-53-1

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规格 价格 是否有货 数量
5 mg ￥1350
2 - 4 周
10 mg ￥2200
2 - 4 周
25 mg ￥4700
2 - 4 周
50 mg 现货 2 - 4 周
100 mg   询价  
200 mg   询价  

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Customer Review

RIPK3-IN-3 相关抗体

Top Publications Citing Use of Products

查看 RIP kinase 亚型特异性产品:

查看所有亚型
RIPK1 RIPK2 RIPK3

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

RIPK3-IN-3 (compound 20) is a selective inhibitor of RIP kinase RIPK3 (IC50=10 nM). RIPK3 mediates the phosphorylation of Mixed Lineage Kinase (MLKL) and causes necroptosis, while RIPK3-IN-3 inhibits p-MLKL oligomerization and thereby inhibits necroptosis. RIPK3-IN-3 also downregulates CXCL5 secretion and inhibits AsPC-1 cell migration and invasion[1].

IC50 & Target

IC50: 10 nM (RIPK3)[1]
体外研究
(In Vitro)

RIPK3-IN-3 相关抗体:

Western Blot Analysis [1]

Cell Line: HT-29 cell
Concentration: 10, 25, 50 μM
Incubation Time: 2 h
Result: Inhibited phosphorylation of RIPK3 and MLKL in a concentration dependent manner.

Cell Viability Assay [1]

Cell Line: U937 cells, HT-29cell
Concentration: 20,50 μM
Incubation Time: 2 h
Result: Decreased PI-positive cells to Hoechst-positive cells ratio.
Rescued the cell from the TCZ-induced cell necroptosis.

Cell Migration Assay [1]

Cell Line: AsPC-1 cell
Concentration: 20,50 μM
Incubation Time: 24 h
Result: Suppressed migration capability of AsPC-1 pancreatic cancer cells in a dose dependent manner.

Cell Invasion Assay[1]

Cell Line: AsPC-1 cell
Concentration: 20,50 μM
Incubation Time: 2 h
Result: Suppressed invasion capability of AsPC-1 pancreatic cancer cells in a dose dependent manner.
体内研究
(In Vivo)
Animal Model: TNF-induced SIRS model (C57BL/6 female mice)[1]
Dosage: 10 or 25 mg/kg, single dose, TNFα (7 μg/mouse, iv)
Administration: Intraperitoneal injection (i.p.)
Result: Protects mice against lethal shock which is induced by TNFα and relieved the TNFα-induced temperature loss in a dose-dependent manner.
Decreases TNFα-induced IL-6 production in the mouse serum.
分子量

305.36

Formula

C16H11N5S
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

RIPK3-IN-3 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

RIPK3-IN-33052303-53-1Mixed Lineage KinaseRIP kinaseMLKsReceptor-interacting protein kinasesRIPKprogrammed necrotic cell deathTNFα-induced systemic inflammatory response syndromeHT-29Inhibitorinhibitorinhibit

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目录号：
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