2. GPCR/G Protein
  3. Prostaglandin Receptor
  4. Rivenprost

Rivenprost  (Synonyms: ONO-4819; ONO-AE1-734)

目录号: HY-114974 纯度: ≥99.0%
COA 产品使用指南

摩尔计算器

Rivenprost (ONO-4819; ONO-AE1-734) 是前列腺素 E 受体 (EP4) 的选择性激动剂，Ki 为 0.7 nM。Rivenprost 具有肝保护和骨合成代谢作用。

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Rivenprost Chemical Structure

Rivenprost Chemical Structure

CAS No. : 256382-08-8

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规格 价格 是否有货 数量
100 μg (2.22 mM * 100 μL in Methyl acetate) ￥1260
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500 μg (2.22 mM * 500 μL in Methyl acetate) ￥3780
In-stock
1 mg (2.22 mM * 1 mL in Methyl acetate) 现货 询价

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Customer Review

Rivenprost 相关抗体

Top Publications Citing Use of Products

查看 Prostaglandin Receptor 亚型特异性产品:

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DP EP FP IP TXA2/TP TXB2

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Rivenprost (ONO-4819; ONO-AE1-734) is a selective agonist for prostaglandin E receptor EP4 with Ki of 0.7 nM. Rivenprost exhibits hepatoprotective and bone anabolic effects[1][2].

IC50 & Target

EP4

0.7 nM (Ki)

体外研究
(In Vitro)

Rivenprost (1 nM–1 μM) 通过上调 Runx2 和 Osterix 的表达，刺激成骨细胞分化，从而增加骨形成[1]。
Rivenprost (1 nM–1 μM) 通过下调 PPARγ 的 mRNA 水平抑制骨中脂肪细胞分化[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Rivenprost 相关抗体:

RT-PCR[1]

Cell Line: C3H10T1/2
Concentration: 1 nM–1 μM
Incubation Time: 7 days
Result: Reduced PPARγ in a dose-dependent manner.
体内研究
(In Vivo)

Rivenprost (10 μg/kg，皮下注射 5 周) 可增加 Sprague-Dawley 大鼠的骨形成，降低年龄依赖性的脂肪细胞水平[1]。
Rivenprost (0.2 mg/kg，腹腔注射，单剂量) 通过炎症细胞因子如 TNF-α 对 Wistar 大鼠中 GalN-/LPS- 诱导的肝损伤具有肝保护作用[2]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Sprague Dawley rats[1]
Dosage: 10 μg/kg
Administration: s.c., twice a day for 5 weeks
Result: Increased osteoblast number, bone volume, mineral apposition rate and bone formation rate.
Decreased adipocyte number.
Animal Model: GalN/LPS-induced acute liver injury in wistar rats[2]
Dosage: 0.2 mg/kg
Administration: i.p., single dosage
Result: Inhibited development of hepatic necrosis, decreased levels of AST, ALT, TNF-α and IFN-γ.
分子量

450.59

Formula

C24H34O6S
CAS 号
性状

液体

颜色

Colorless to light yellow

运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Solution, -20°C, 2 years
纯度 & 产品资料

纯度: ≥99.0%

COA (290 KB)

产品使用指南 (1538 KB)
参考文献

Rivenprost 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Rivenprost256382-08-8ONO-4819 ONO-AE1-734ONO4819ONO 4819Prostaglandin ReceptorC3H10T1/2hepatoprotectiveInhibitorinhibitorinhibit

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